Many instructional guides have been published on how to write scientific papers. Likewise, many published articles have focused on the reasons why submitted manuscripts are rejected. However, fewer publications have been presented to guide authors on how to address reviewers' comments in a manuscript revision. Even fewer counsel authors on how to deal with a rejection decision. In this article, the authors present a literature review on the strategies to get a manuscript accepted, despite an initial unfavorable review. The authors share their experience with addressing reviewers' comments to get a manuscript accepted and published. Finally, the authors discuss the process of peer review and offer tips on how to be an effective peer reviewer.