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Advances in enzymatic transformation of penicillins to 6-aminopenicillanic acid (6-APA)
July 2000
July 2000
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Abstract
This article elaborates on the important recent developments in the enzymatic transformation
of penicillins to 6-aminopenicillanic acid (6-APA), which is the basic raw material
for the industrial production of semisynthetic penicillins such as amoxycillin and
ampicillin. Particular emphasis is placed on the improvements in purification, stability,
and immobilization of the enzymes, (i.e. penicillin acylases) used for these transformations.