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      Vasculitis y vasculopatía con compromiso cutáneo, nasal y pulmonar inducida por consumo de cocaína-levamisol. Translated title: Vasculitis and vasculopathy with cutaneous, nasal and pulmonary involvementinduced by cocaine-levamisole use.

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          Abstract

          Resumen La cocaína pura y la contaminada con levamisol producen múltiples dermatosis, siendo las más frecuentes las lesiones destructivas de línea media y las vasculitis similares a las ANCA. Las bases fisiopatológicas de estas manifestaciones se sustentan en el daño vascular secundario a vasculitis y/o vasculopatía, originado por ambas sustancias y en muchos casos se puede encontrar solapamiento de las formas clínicas, lo que puede llevar a diagnósticos erróneos. Los patrones de positividad de los auto anticuerpos, el patrón de las lesiones cutáneas y el contexto social, serán claves en el abordaje y tratamiento adecuado de estos pacientes.

          Translated abstract

          Abstract Pure cocaine and contaminated cocaine with levamisole produce multiple cutaneous and systemic manifestations, being midline destructive lesions and ANCA-like vasculitis the most frequent ones. The pathophysiological bases of these manifestations are based on secondary vascular damage to vasculitis and/or vasculopathy caused by both substances and in many cases it may be found an overlapping of the clinical forms, which might lead to erroneous diagnoses. The patterns of positivity of the autoantibodies, the pattern of skin lesions and the social context of the patient will be key in the proper approach and management of these patients. The following case describes a patient with cutaneous, nasal and pulmonary manifestations due to cocaine / levamisole consumption. Also, a review of the literature is carried out.

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          Cocaine-Levamisole-Induced Vasculitis/Vasculopathy Syndrome.

          To understand the clinical spectrum of cocaine-levamisole-induced vasculitis. Worldwide recreational drug consumption is high among the adult population from various social strata. The use of cocaine with levamisole, a frequently added antiparasitic diluent, favors the manifestations of vasculitic lesions, especially in the skin.
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            Cocaine and ANCA associated vasculitis-like syndromes – A case series

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              Usefulness of antineutrophil cytoplasmic autoantibodies in diagnosing and managing systemic vasculitis. CurrOpinRheumatol.

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                Author and article information

                Journal
                rad
                Revista argentina de dermatología
                Rev. argent. dermatol.
                Asociación Argentina de Dermatología (Ciudad Autónoma de Buenos Aires, , Argentina )
                1851-300X
                December 2021
                : 102
                : 4
                : 21-30
                Affiliations
                [1] orgnameUniversidad Nacional de C
                Article
                S1851-300X2021000400021 S1851-300X(21)10200400021
                efdfcde2-c7e4-48c5-8620-fbaba5f30e15

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 06 November 2020
                : 23 July 2022
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 19, Pages: 10
                Product

                SciELO Argentina

                Categories
                Caso clínico patológico

                levamisol,vasculitis,ANCA,cocaine,cocaína
                levamisol, vasculitis, ANCA, cocaine, cocaína

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