Effect of Pacing on Epinephrine- Stimulated Atrial Natriuretic Factor Release

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Abstract

Previous in vitro studies showed that epinephrine stimulation can induce atrial natriuretic factor (ANF) release only form the right atrium but not from the left. In addition, sinus node has been shown to play an important role in the release of ANF. In vitro studies were done in isolated left and right rat atria to determine if pacing can induce the left atria to release ANF during epinephrine stimulation. ANF concentrations in the perfusate were measured by a radioimmunoassay method. Epinephrine increased ANF release in the right atria (from 6.3 ± 0.8 to 10.8 ± 0.9 pg/min/mg), but not in the unpaced left atria (4.2 ± 0.4 and 4.2 ± 0.3 pg/min/mg). However, when the atria were paced, ANF release rose in both the left (from 6.2 ± 0.5 to 11.5 ± 1.4 pg/min/mg) and right (from 8.4 ± 1.15 to 16.6 ± 1.8 pg/min/mg) atria with epinephrine addition. These results suggest that atrial contraction and tension play an important role in epinephrine-stimulated ANF release.

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Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1992

Publication date (Print): 1992

Publication date (Electronic): 14 November 2008

Volume: 81

Issue: 2-3

Pages: 85-88

Affiliations

Department of Medicine, University of British Columbia, Vancouver, Canada

Article

Publisher ID: 175781 Other ID: Cardiology 1992;81:85–88

DOI: 10.1159/000175781

PubMed ID: 1286482

SO-VID: f0cff947-b441-4b68-8596-c4a9ea692f9d

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 20 April 1992

Date accepted : 19 May 1992

Page count

Pages: 4

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