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      Human Metapneumovirus in Severe Respiratory Syncytial Virus Bronchiolitis

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          Abstract

          Reverse transcription-polymerase chain reaction was used to detect segments of the M (matrix), N (nucleoprotein), and F (fusion) genes of human metapneumovirus in bronchoalveolar fluid from 30 infants with severe respiratory syncytial virus bronchiolitis. Seventy percent of them were coinfected with metapneumovirus. Such coinfection might be a factor influencing the severity of bronchiolitis.

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          A newly discovered human pneumovirus isolated from young children with respiratory tract disease

          Bernadette van den Hoogen, Jan C de Jong, Jan Groen … (2001)
          From 28 young children in the Netherlands, we isolated a paramyxovirus that was identified as a tentative new member of the Metapneumovirus genus based on virological data, sequence homology and gene constellation. Previously, avian pneumovirus was the sole member of this recently assigned genus, hence the provisional name for the newly discovered virus: human metapneumovirus. The clinical symptoms of the children from whom the virus was isolated were similar to those caused by human respiratory syncytial virus infection, ranging from upper respiratory tract disease to severe bronchiolitis and pneumonia. Serological studies showed that by the age of five years, virtually all children in the Netherlands have been exposed to human metapneumovirus and that the virus has been circulating in humans for at least 50 years.
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            Respiratory syncytial virus infection.

            Eric AF Simões (1999)
            Respiratory syncytial virus (RSV), long recognised as the major viral pathogen of the lower respiratory tract of infants, has also been implicated in severe lung disease in adults, especially the elderly. This fact, and the demonstration that passive prophylaxis with either polyclonal or monoclonal antibody to RSV prevents severe lung disease in high-risk infants and children, has led to renewed interest in the immune mechanisms surrounding protection, and the development of vaccines
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              Characterization of Human Metapneumoviruses Isolated from Patients in North America

              Teresa C T Peret, Guy Boivin, Yan. Li … (2002)
              Abstract Human metapneumovirus (HMPV) was recently identified in The Netherlands and was linked to acute respiratory tract illness. In this study, 11 isolates from 10 patients with respiratory disease from Quebec, Canada, were tested by a reverse-transcriptase polymerase chain reaction based on the fusion protein gene. Identified sequences were consistent with HMPV. The patients were 2 months to 87 years of age (median age, 58 years) and presented with acute respiratory tract illness during the winter season. Sequence studies of the nucleocapsid, fusion, and polymerase genes identified 2 main lineages of HMPV and cocirculation of both lineages during the same year. These findings support a previous finding that HMPV is a human respiratory pathogen that merits further study.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Emerg Infect Dis
                Journal ID (publisher-id): EID
                Title: Emerging Infectious Diseases
                Publisher: Centers for Disease Control and Prevention
                ISSN (Print): 1080-6040
                ISSN (Electronic): 1080-6059
                Publication date (Print): March 2003
                Volume: 9
                Issue: 3
                Pages: 372-375
                Affiliations
                [* ]University of Liverpool, Liverpool, United Kingdom
                Author notes
                Address for correspondence: C.A. Hart, Department of Medical Microbiology, University of Liverpool, Daulby Street, Liverpool, L69 3GA, United Kingdom, fax: 44 151 706 5805; e-mail: cahmm@ 123456liv.ac.uk
                Article
                Publisher ID: 02-0289
                DOI: 10.3201/eid0903.020289
                PMC ID: 2958536
                PubMed ID: 12643835
                SO-VID: f10ed517-2f96-4b6d-8f0e-c40931c1edc8
                History
                Categories
                Subject: Dispatch

                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: human metapneumovirus,respiratory syncytial virus,severe bronchiolitis,dispatch,rt-pcr
                Data availability:
                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: human metapneumovirus,respiratory syncytial virus, severe bronchiolitis, dispatch, rt-pcr

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