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Altered white-matter architecture in treatment-naive adolescents with clinical depression.
M Aghajani
1 ,
I M Veer
2 ,
N D J van Lang
1 ,
P H F Meens
1 ,
B G van den Bulk
1 ,
S A R B Rombouts
2 ,
R R J M Vermeiren
1 ,
N J van der Wee
2
Aug 2014
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Abstract
Depressive disorders are highly prevalent in adolescence and confer a heightened risk of recurrence in adulthood. Insight into the developmental neurocircuitry of depression could advance our understanding of depression and aid the development of effective treatment strategies. Whereas white-matter (WM) abnormalities are strongly implicated in adult depression, we still lack a firm understanding of WM architecture in adolescent depression. Using diffusion tensor imaging (DTI), we set out to investigate WM microstructure in a sample of clinically depressed adolescents relative to matched controls.