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Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials
Pratik Sinha ,
V Eric Kerchberger ,
Andrew Willmore ,
Julia Chambers ,
Hanjing Zhuo ,
Jason Abbott ,
Chayse Jones ,
Nancy Wickersham ,
Nelson Wu ,
Lucile Neyton ,
Charles R Langelier ,
Eran Mick ,
June He ,
Alejandra Jauregui ,
Matthew M Churpek ,
Antonio D Gomez ,
Carolyn M Hendrickson ,
Kirsten N Kangelaris ,
Aartik Sarma ,
Aleksandra Leligdowicz ,
Kevin L Delucchi ,
Kathleen D Liu ,
James A Russell ,
Michael A Matthay ,
Keith R Walley ,
Lorraine B Ware ,
Carolyn S Calfee
November 2023
November 2023
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Abstract
<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto"
id="d10459049e392">In sepsis and acute respiratory distress syndrome (ARDS), heterogeneity
has contributed
to difficulty identifying effective pharmacotherapies. In ARDS, two molecular phenotypes
(hypoinflammatory and hyperinflammatory) have consistently been identified, with divergent
outcomes and treatment responses. In this study, we sought to derive molecular phenotypes
in critically ill adults with sepsis, determine their overlap with previous ARDS phenotypes,
and evaluate whether they respond differently to treatment in completed sepsis trials.
</p>