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      Associations among childhood abuse experience and Interleukin-6 in middle school students

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          Abstract

          Objective The present study aimed to determine the prevalence of childhood abuse and examined its correlation with inflammatory factor IL-6 level in middle schools students.

          Methods A total of 911 junior and high school students from a middle school in Shenyang were enrolled in this study to investigate the experience of childhood abuse and its association with IL -6 level in fasting blood samples in December 2017.

          Results The prevalence of childhood maltreatment was 21.0%, the prevalence of physical, emotional and sexual abuse was 21.8%, 20.3% and 9.5%, respectively. Physical abuse, emotional abuse and total abuse were associated with high levels of IL-6 in junior high school boys, χ 2 values were 3.88, 6.78, and 9.10, respectively ( P <0.05). There was no significant correlation between abuse experiences with IL-6 levels among junior high school girls and senior high school students. Regression analysis showed that physical abuse, emotional abuse and total abuse were positively associated with IL-6 concentration among junior high school boys ( OR = 2.23, 3.49, 1.58, P<0.05).

          Conclusion Physical and emotional abuse in childhood associates with the increase of IL-6 level among junior school boys. Abnormal inflammatory factor level might be potential mechanism linking childhood abuse with adverse health outcomes.

          Abstract

          【摘要】目的了解中学生童年期虐待的流行特征及其与促炎因子白细胞介素(IL-6)水平的关联,为深人认识童年 期虐待的不良健康效应提供循证依据。 方法采用整群抽样方法,于2017年12月选取沈阳市某中学911名在校生为研 究对象,现场问卷调査其童年期虐待经历,收集晨起空腹血样检测IL-6水平。 结果童年期虐待总体检出率为21.0%,身区 体、情感和性虐待检出率分别为21.8%,20.3%,9.5%。初中男生躯体虐待、情感虐待和总虐待与髙水平的IL-6相关 ( χ 2值 分别为3.88,6.78,9.10,P值均<0.05),初中女生和髙中生虐待经历与IL-6的水平相关无统计学意义。多因素Logistic回 归模型结果显示,躯体虐待、情感虐待和总虐待经历与初中男生IL-6升髙均呈正性相关( OR值分别为2.23,3.49,1.58,P 值均<0.05)。 结论童年期躯体虐待和情感虐待是初中男生IL-6水平升髙的重要影响因素,炎症因子水平异常可能是初 中男生童年期虐待不良健康效应的潜在基础。

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          Author and article information

          Journal
          CJSH
          Chinese Journal of School Health
          Chinese Journal of School Health (China )
          1000-9817
          01 March 2020
          01 January 2020
          : 40
          : 3
          : 384-387
          Affiliations
          [1] 1Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei (230032), China
          Author notes
          *Corresponding author: HAO Jiahu, E-mail: jia712S@ 123456126.com
          Article
          j.cnki.1000-9817.2019.03.019
          10.16835/j.cnki.1000-9817.2019.03.019
          f279f5df-4a81-4bc9-9a0d-5e553f3d5112
          © 2019 Chinese Journal of School Health

          This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (CC BY-NC 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc/4.0/.

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          Self URI (journal-page): http://www.cjsh.org.cn
          Categories
          Journal Article

          Ophthalmology & Optometry,Pediatrics,Nutrition & Dietetics,Clinical Psychology & Psychiatry,Public health
          Interleukin-6,Child abuse,Students,Mental health,Regression analysis

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