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      Antagonistic Effects of Sulpiride – Racemic and Enantiomers – on Renal Response to Low-Dose Dopamine Infusion in Normal Women

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          Abstract

          In healthy women during moderate hydrosaline retention we have evaluated the antagonistic effects of sulpiride – enantiomers and racemic – on the renal action of a low-dose dopamine (DA) infusion (0.1 μg/kg/min). The studies were performed, in hypotonic polyuria, by the clearance (Cl) method in (1) hydrosaline retention (n = 23), (2) retention + dl-sulpiride (n = 8), (3) retention + d-sulpiride and (4) retention + l-sulpiride (in the latter two cases n = 7 subjects submitted to paired studies). Hydrosaline retention was induced by deoxycorticosterone acetate treatment. A common pattern of sulpiride treatment was applied. The DA renal hyperemia is abolished by l-sulpiride while it is transitorily attenuated by d-sulpiride. In both conditions 3 and 4 the increase in glomerular filtration rate, the inhibition of fractional isosmotic sodium reabsorption and the increase in urinary sodium excretion – induced by DA in condition 1 – are suppressed. On the contrary, DA inhibition of fractional anisosmotic sodium reabsorption is not affected by sulpiride. The data indicate that DA renal hyperemia results from the action of DA on DA<sub>2</sub> receptors; the DA inhibition of sodium transport by the diluting segments does not appear to be mediated by typical DA receptors.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1989
          1989
          09 December 2008
          : 51
          : 4
          : 491-498
          Affiliations
          Cattedra di Semeiotica Medica, Istituto di Clinica Medica II dell’Università di Bologna, Italia
          Article
          185382 Nephron 1989;51:491–498
          10.1159/000185382
          2739826
          © 1989 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Receptors DA1 and DA2 , Dopamine, Sulpiride enantiomers

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