Treatment of Hematomas Using a Synthetic Hybrid-Scale Fiber Matrix

Abstract

Effective treatment of traumatic subcutaneous hematomas is important to avoid complications, including skin necrosis, infection, scarring, hyperpigmentation, tissue edema, and prolonged recovery. Hematoma treatment may include evacuation followed by application of a skin substitute. Given the challenges associated with conventional skin substitutes, a fully-synthetic, resorbable, electrospun matrix composed of hybrid-scale fibers may offer a new option for treating hematomas. The present study reports on two clinical case reports assessing the use of the synthetic hybrid-scale fiber matrix for the treatment of hematomas.

The hematomas located on the pretibial leg and dorsal foot were debrided in the operating room with evacuation of the hematomas, and the synthetic matrix was applied to the wounds. Following treatment, the wounds were observed for healing progress, including measuring and photographing the wounds and documenting clinical observations. The synthetic hybrid-scale fiber matrix was re-applied as needed based on clinician discretion.

In both cases, treatment following the use of the synthetic hybrid-scale fiber matrix resulted in complete healing. Complete closure of all wounds was observed after two to three applications of the synthetic matrix within six to 16 weeks, and no adverse events were noted.

In this study, hematomas of the foot and the leg demonstrated successful healing following treatment with the synthetic hybrid-scale fiber matrix. The successful clinical outcomes suggest that this biomaterial may offer benefits as part of a new treatment paradigm for hematomas and warrants further investigation.