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      Menthol's potential effects on nicotine dependence: a tobacco industry perspective

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          Abstract

          Objective

          To examine what the tobacco industry knows about the potential effects menthol may have on nicotine dependence.

          Methods

          A snowball strategy was used to systematically search the Legacy Tobacco Documents Library ( http://legacy.library.ucsf.edu/) between 22 February and 29 April, 2010. Of the approximately 11 million documents available in the Legacy Tobacco Documents Library, the iterative searches returned tens of thousands of results. We qualitatively analysed a final collection of 309 documents relevant the effects of menthol on nicotine dependence.

          Results

          The tobacco industry knows that menthol overrides the harsh taste of tobacco and alleviates nicotine's irritating effects, synergistically interacts with nicotine, stimulates the trigeminal nerve to elicit a ‘liking’ response for a tobacco product, and makes low tar, low nicotine tobacco products more acceptable to smokers than non-mentholated low delivery products.

          Conclusion

          Menthol is not only used in cigarettes as a flavour additive; tobacco companies know that menthol also has sensory effects and interacts with nicotine to produce tobacco products that are easier to smoke, thereby making it easier to expose smokers, especially those who are new and uninitiated, to the addictive power of nicotine.

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          Most cited references61

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          Clinical pharmacology of nicotine: implications for understanding, preventing, and treating tobacco addiction.

          N Benowitz (2008)
          Understanding the basic and clinical pharmacology of nicotine provides a basis for improved prevention and treatment of tobacco addiction. Nicotine acts on nicotinic cholinergic receptors in the brain to release dopamine and other neurotransmitters that sustain addiction. Neuroadaptation and tolerance involve changes in both nicotinic receptors and neural plasticity. Nicotine addiction can occur in the context of physical dependence characterized by self-medication to modulate negative affect and/or to relieve withdrawal symptoms, as well as, in light or occasional smokers, primarily for positive reinforcement in specific situations. Nicotine is metabolized primarily by CYP2A6. Its clearance exhibits considerable individual variability that is determined by genetic, racial, and hormonal (sex) factors. Genetically slow metabolism of nicotine appears to be associated with a lower level of dependence. Nicotine dependence is highly heritable and appears to be influenced by genes coding for some nicotine receptor subtypes, some neurotransmitter genes, and genes involved in neural connectivity. Novel pharmacotherapies for nicotine dependence include partial agonists for nicotinic receptors and nicotine vaccines. Pharmacogenetic studies suggest various candidate genes and a nicotine metabolism phenotype that influence outcome. Human pharmacology studies of nicotine and smoking behavior also provide a basis for assessing the benefits and risks of long-term nicotine use for harm reduction and for a potential cigarette regulatory strategy that includes reducing nicotine content of cigarettes to nonaddictive levels.
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            Implications of the tobacco industry documents for public health and policy.

            Lisa Bero (2002)
            The release of previously secret internal tobacco industry documents has given the public health community unprecedented insight into the industry's motives, strategies, tactics, and data. The documents provide information that is not available from any other source and describe the history of industry activities over the past 50 years. The documents show that the tobacco industry has been engaged in deceiving policy makers and the public for decades. This paper begins with a brief history of the tobacco industry documents and describes the methodological challenges related to locating and analyzing an enormous number of poorly indexed documents. It provides an overview of selected important findings of document research conducted to date, including analyses of industry documents on nicotine and addiction, product design, marketing and promotion, passive smoke, and internal activities. The paper concludes with a discussion of the implications of tobacco document research for public health and the application of such research to fields other than tobacco control.
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              Tobacco industry documents: treasure trove or quagmire?

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                Author and article information

                Journal
                Tob Control
                tc
                tobaccocontrol
                Tobacco Control
                BMJ Group (BMA House, Tavistock Square, London, WC1H 9JR )
                0964-4563
                1468-3318
                May 2011
                May 2011
                : 20
                : Suppl_2 , Menthol cigarettes
                : ii29-ii36
                Affiliations
                Department of Social and Behavioral Sciences, Center for Tobacco Control Research and Education, University of California, San Francisco, San Francisco, California, USA
                Author notes
                Correspondence to Dr Valerie B Yerger, Department of Social and Behavioral Sciences, Box 0612, University of California, San Francisco, San Francisco, CA 94143-0612, USA; valerie.yerger@ 123456ucsf.edu

                Linked articles: [Related article:]041939, [Related article:]041947, [Related article:]041954, [Related article:]041962, [Related article:]041988, [Related article:]041921.

                This manuscript will be useful for the Tobacco Control readership in all countries that are parties to the FCTC, as they implement the product regulation provisions of the FCTC.

                Article
                tobaccocontrol41970
                10.1136/tc.2010.041970
                3088468
                21504929
                f3dbc877-5b79-4793-8bf9-35d5ab48d198
                © 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

                This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.

                History
                : 17 November 2010
                : 3 February 2011
                Categories
                Research Paper
                1506

                Public health
                tobacco,addiction,smoking,nicotine dependence,menthol,tobacco industry,volatile organic compounds,qualitative study,young adults,tobacco products

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