NanoZnO-modified titanium implants for enhanced anti-bacterial activity, osteogenesis and corrosion resistance

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Titanium (Ti) implants are widely used in dentistry and orthopedics owing to their excellent corrosion resistance, biocompatibility, and mechanical properties, which have gained increasing attention from the viewpoints of fundamental research and practical applications. Also, numerous studies have been carried out to fine-tune the micro/nanostructures of Ti and/or incorporate chemical elements to improve overall implant performance. Zinc oxide nanoparticles (nano-ZnO) are well-known for their good antibacterial properties and low cytotoxicity along with their ability to synergize with a variety of substances, which have received increasingly widespread attention as biomodification materials for implants. In this review, we summarize recent research progress on nano-ZnO modified Ti-implants. Their preparation methods of nano-ZnO modified Ti-implants are introduced, followed by a further presentation of the antibacterial, osteogenic, and anti-corrosion properties of these implants. Finally, challenges and future opportunities for nano-ZnO modified Ti-implants are proposed.

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Exploring the full spectrum of macrophage activation.

David Mosser, Justin Edwards (2008)

Macrophages display remarkable plasticity and can change their physiology in response to environmental cues. These changes can give rise to different populations of cells with distinct functions. In this Review we suggest a new grouping of macrophage populations based on three different homeostatic activities - host defence, wound healing and immune regulation. We propose that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation. We characterize each population and provide examples of macrophages from specific disease states that have the characteristics of one or more of these populations.

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Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.

Sukdeb Pal, Yu Tak, Joon Myong Song (2007)

In this work we investigated the antibacterial properties of differently shaped silver nanoparticles against the gram-negative bacterium Escherichia coli, both in liquid systems and on agar plates. Energy-filtering transmission electron microscopy images revealed considerable changes in the cell membranes upon treatment, resulting in cell death. Truncated triangular silver nanoplates with a {111} lattice plane as the basal plane displayed the strongest biocidal action, compared with spherical and rod-shaped nanoparticles and with Ag(+) (in the form of AgNO(3)). It is proposed that nanoscale size and the presence of a {111} plane combine to promote this biocidal property. To our knowledge, this is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and our results demonstrate that silver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.

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Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism

Amna Sirelkhatim, Shahrom Mahmud, Azman Seeni … (2015)

Antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. Many microorganisms exist in the range from hundreds of nanometers to tens of micrometers. ZnO-NPs exhibit attractive antibacterial properties due to increased specific surface area as the reduced particle size leading to enhanced particle surface reactivity. ZnO is a bio-safe material that possesses photo-oxidizing and photocatalysis impacts on chemical and biological species. This review covered ZnO-NPs antibacterial activity including testing methods, impact of UV illumination, ZnO particle properties (size, concentration, morphology, and defects), particle surface modification, and minimum inhibitory concentration. Particular emphasize was given to bactericidal and bacteriostatic mechanisms with focus on generation of reactive oxygen species (ROS) including hydrogen peroxide (H2O2), OH− (hydroxyl radicals), and O2 −2 (peroxide). ROS has been a major factor for several mechanisms including cell wall damage due to ZnO-localized interaction, enhanced membrane permeability, internalization of NPs due to loss of proton motive force and uptake of toxic dissolved zinc ions. These have led to mitochondria weakness, intracellular outflow, and release in gene expression of oxidative stress which caused eventual cell growth inhibition and cell death. In some cases, enhanced antibacterial activity can be attributed to surface defects on ZnO abrasive surface texture. One functional application of the ZnO antibacterial bioactivity was discussed in food packaging industry where ZnO-NPs are used as an antibacterial agent toward foodborne diseases. Proper incorporation of ZnO-NPs into packaging materials can cause interaction with foodborne pathogens, thereby releasing NPs onto food surface where they come in contact with bad bacteria and cause the bacterial death and/or inhibition.

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Author and article information

Contributors

Xinqiang Liu: dentistlxq@163.com

Qihui Zhou:

ORCID: http://orcid.org/0000-0003-2474-4197

qihuizhou@qdu.edu.cn

Journal

Journal ID (nlm-ta): J Nanobiotechnology

Journal ID (iso-abbrev): J Nanobiotechnology

Title: Journal of Nanobiotechnology

Publisher: BioMed Central (London )

ISSN (Electronic): 1477-3155

Publication date (Electronic): 30 October 2021

Publication date PMC-release: 30 October 2021

Publication date Collection: 2021

Volume: 19

Electronic Location Identifier: 353

Affiliations

[1 ]GRID grid.412521.1, ISNI 0000 0004 1769 1119, Institute for Translational Medicine, Department of Orthodontics, , The Affiliated Hospital of Qingdao University, Qingdao University, ; Qingdao, 266003 China

[2 ]GRID grid.410645.2, ISNI 0000 0001 0455 0905, School of Stomatology, , Qingdao University, ; Qingdao, 266003 China

[3 ]GRID grid.412521.1, ISNI 0000 0004 1769 1119, Department of Oral Implantology, , The Affiliated Hospital of Qingdao University, ; Qingdao, 266003 China

[4 ]GRID grid.412508.a, ISNI 0000 0004 1799 3811, Shandong University of Science and Technology, ; Qingdao, 266590 China

Author information

Qihui Zhou http://orcid.org/0000-0003-2474-4197

Article

Publisher ID: 1099

DOI: 10.1186/s12951-021-01099-6

PMC ID: 8557588

PubMed ID: 34717648

SO-VID: f406338c-3b71-439f-9c88-b2349226bc20

License:

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

History

Date received : 23 August 2021

Date accepted : 20 October 2021

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;

Award ID: 31900957

Award Recipient : Qihui Zhou

Funded by: FundRef http://dx.doi.org/10.13039/501100007129, Natural Science Foundation of Shandong Province;

Award ID: ZR2019QC007

Award Recipient : Qihui Zhou

Funded by: Innovation and technology program for the excellent youth scholars of higher education of Shandong province

Award ID: 2019KJE015

Award Recipient : Qihui Zhou

Funded by: FundRef http://dx.doi.org/10.13039/501100010031, Postdoctoral Research Foundation of China;

Award ID: 2019M652326

Award Recipient : Qihui Zhou

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ScienceOpen disciplines: Biotechnology

Keywords: titanium implants,nano-zno,anti-bacteria,osteogenesis,anti-corrosion

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ScienceOpen disciplines: Biotechnology

Keywords: titanium implants, nano-zno, anti-bacteria, osteogenesis, anti-corrosion

NanoZnO-modified titanium implants for enhanced anti-bacterial activity, osteogenesis and corrosion resistance

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Most cited references 153

Exploring the full spectrum of macrophage activation.

Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.

Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism

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