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      Long-Term Cefuroxime Axetil in Subacute Cutaneous Lupus erythematosus

      case-report

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          Abstract

          Background: Subacute cutaneous lupus erythematosus (SCLE) is a subset of lupus erythematosus characterized mainly by prominent photoaggravated cutaneous manifestations. Standard therapies for SCLE include topical or systemic steroids and antimalarial drugs. Both methods show limited efficacy in clearing cutaneous lesions and occasionally produce serious side effects. Aim: To assess the efficacy of cefuroxime axetil, an oral cephalosporin with antibacterial and immunosuppressive activity, in patients with SCLE. Methods: Three patients with SCLE were treated with cefuroxime axetil at a daily dose of 500 mg for 30–60 days. Results: In all patients complete clearing of skin lesions was achieved and no side effects were observed. Conclusion: We suggest that long-term cefuroxime axetil administration might be an alternative treatment for patients with SCLE skin lesions.

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          Dystrophic Calcinosis cutis in Subacute Lupus

          A.V. Marzano, L.V. Kolesnikova, G Gasparini … (1999)
          Dystrophic calcinosis cutis is known to be associated with various connective tissue disorders but to the best of our knowledge has never been reported in subacute cutaneous lupus erythematosus (SCLE), a distinctive cutaneous subset in the spectrum of lupus erythematosus. It occurs without calcium and phosphorus metabolic abnormalities and may be localized or generalized. We report a patient with SCLE who developed calcinosis cutis and had normal serum calcium and phosphorus levels and, interestingly, a normal concentration of blood ionized calcium. This latter, which represents the active form in the total amount of blood calcium, is a parameter only rarely assessed in patients with dystrophic calcinosis cutis. Thus, other pathogenic factors should be investigated to clarify the pathophysiology of the dystrophic type of calcification.
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            The Cutaneous Pathology Associated With Seropositivity for Antibodies to SSA (Ro)

            Cynthia Magro, A. Crowson (1999)
            Article 0 comments Cited 2 times – based on 0 reviews     Review now
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              Author and article information

              Journal
              Journal ID (publisher-id): DRM
              Journal ID (nlm-ta): Dermatology
              Journal ID (doi): 10.1159/issn.1018-8665
              Title: Dermatology
              Publisher: S. Karger AG
              ISSN (Print): 1018-8665
              ISSN (Electronic): 1421-9832
              Publication date Subscription-year: 2000
              Publication date (Print): 2000
              Publication date (Electronic): 14 April 2000
              Volume: 200
              Issue: 2
              Pages: 129-131
              Affiliations
              Department of Dermatology, CSK MSWiA, Warsaw, Poland
              Article
              Publisher ID: 18345 Other ID: Dermatology 2000;200:129–131
              DOI: 10.1159/000018345
              PubMed ID: 10773701
              SO-VID: f4bf8419-103b-480e-840d-2d229856108a
              Copyright © © 2000 S. Karger AG, Basel
              License:

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              History
              Page count
              References: 18, Pages: 3
              Categories
              Subject: Pharmacology and Treatment

              ScienceOpen disciplines: Oncology & Radiotherapy,Pathology,Surgery,Dermatology,Pharmacology & Pharmaceutical medicine
              Keywords: Subacute cutaneous lupus erythematosus,Cefuroxime axetil,Cephalosporin
              Data availability:
              ScienceOpen disciplines: Oncology & Radiotherapy, Pathology, Surgery, Dermatology, Pharmacology & Pharmaceutical medicine
              Keywords: Subacute cutaneous lupus erythematosus, Cefuroxime axetil, Cephalosporin

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