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      • Record: found
      • Abstract: found
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      Is Open Access

      A genome-wide association study in multiple system atrophy

      research-article
      Author(s): , MD, PhD, , MD, PhD , , PhD, , PhD, , MS, , MS, , MD, , PhD, , MD, , PhD, , MD, , MD, , MD, , MD, PhD, , MD, PhD, , MD, PhD, , MD, PhD, , MD, PhD, , MD, PhD, , PhD, , PhD, , MD, , MD, , MD, PhD, , MD, , MD, , MD, , MD, , MD, , MD, , MD, , MD, PhD, , MD, , MD, , MD, , MD, PhD, , MD, , MD, PhD, , PhD, MD(Hon), , MD, , MD, PhD, , MD, , MD, PhD, , PhD, , MD, PhD
      Other contributor(s): , MD, PhD (Collab), , MD (Collab), , MD (Collab)
      Publication date PMC-release:
      Journal: Neurology
      Publisher: Lippincott Williams & Wilkins

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Objective:

          To identify genetic variants that play a role in the pathogenesis of multiple system atrophy (MSA), we undertook a genome-wide association study (GWAS).

          Methods:

          We performed a GWAS with >5 million genotyped and imputed single nucleotide polymorphisms (SNPs) in 918 patients with MSA of European ancestry and 3,864 controls. MSA cases were collected from North American and European centers, one third of which were neuropathologically confirmed.

          Results:

          We found no significant loci after stringent multiple testing correction. A number of regions emerged as potentially interesting for follow-up at p < 1 × 10 −6, including SNPs in the genes FBXO47, ELOVL7, EDN1, and MAPT. Contrary to previous reports, we found no association of the genes SNCA and COQ2 with MSA.

          Conclusions:

          We present a GWAS in MSA. We have identified several potentially interesting gene loci, including the MAPT locus, whose significance will have to be evaluated in a larger sample set. Common genetic variation in SNCA and COQ2 does not seem to be associated with MSA. In the future, additional samples of well-characterized patients with MSA will need to be collected to perform a larger MSA GWAS, but this initial study forms the basis for these next steps.

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          Most cited references20

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          Genotype imputation.

          Yun Li, Cristen Willer, Serena Sanna … (2009)
          Genotype imputation is now an essential tool in the analysis of genome-wide association scans. This technique allows geneticists to accurately evaluate the evidence for association at genetic markers that are not directly genotyped. Genotype imputation is particularly useful for combining results across studies that rely on different genotyping platforms but also increases the power of individual scans. Here, we review the history and theoretical underpinnings of the technique. To illustrate performance of the approach, we summarize results from several gene mapping studies. Finally, we preview the role of genotype imputation in an era when whole genome resequencing is becoming increasingly common.
          Article 0 comments Cited 378 times – based on 0 reviews     Review now
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            The future of genetic studies of complex human diseases.

            N Risch, K Merikangas (1996)
            Article 0 comments Cited 371 times – based on 0 reviews     Review now
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              Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy.

              M Yoshimoto, K Wakabayashi, H. Takahashi … (1998)
              Lewy bodies in Parkinson' s disease (PD) are strongly immunoreactive with antibodies against alpha-synuclein, which is mutated in some familial cases of the disease. We carried out immunohistochemical examinations of the brains of multiple system atrophy (MSA) patients using anti-alpha-synuclein antibodies. Strong alpha-synuclein immunoreactivity was found in glial cytoplasmic inclusions (GCIs), which are of oligodendroglial origin and occur exclusively in MSA. Alpha-synuclein-immunoreactive neuronal cytoplasmic inclusions (NCIs) were also found occasionally in the substantia nigra, pontine and inferior olivary nuclei, and dentate fascia. These findings indicate that alpha-synuclein is also a major component of GCIs and NCIs in MSA and strongly suggest that alpha-synuclein aggregation is a common process in certain neurodegenerative diseases, including PD and MSA.
              Article 0 comments Cited 106 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Anna Sailer:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. Multiple System Atrophy Trust Medical Research Council UK Wellcome Trust

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Sonja W. Scholz:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. Research support by Merck research laboratories.

                Research Support, Government Entities:

                1. NINDS, R25 research training award, trainee, 2014-2015

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Michael A. Nalls:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NIH employee (2005-current)

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Claudia Schulte:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

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                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

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                Monica Federoff:
                Comment :

                Scientific Advisory Boards:

                1. NONE

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                1. NONE

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                1. NONE

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                T. Ryan Price:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

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                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Andrew Lees:
                Comment :

                Scientific Advisory Boards:

                1. Britannia, UCB phrama, Teva, Lundbeck, BIAL, Roche, Nordiclnfu Care, NeuroDerm, Decision Resources

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. Britannia, UCB pharma, Teva, Lundbeck, BIAL, Roche, Nordiclnfu Care, NeuroDerm, Decision Resources

                Editorial Boards:

                1. 2006 Archivas de Nevropsiquiatria (Brazil) 1995-03 Co-Editor in Chief, Movement Disorders Journal and Historical Section Editor 1994-98 Founder Editor, Behavioural Neurology 1994- Neurologia Espana 1994-00 Revista Neurologica, Argentina 1994-95 European Journal of Neurology 1993- Revue Neurologique 1993-03 Brain 1991-95 Journal Neurology, Neurosurgery & Psychiatry 1989-95 Journal of Neurology 1988-95 Journal of Neural Transmission

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. Institute of Neurology, UCL

                Consultancies:

                1. Britannia Pharmaceutical, BIAL Portela

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. Frances and Renee Hock Fund

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

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                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

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                Owen A. Ross:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. Editorial advisory board member: Parkinsonism and Related Disorders Molecular Neurodegeneration American Journal of Neurodegenerative Disease PLoS ONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. (1) NINDS Udall Parkinson's Disease Research Center of Excellence P50 #NS072187; 2012-1017. (2)NINDS R01 NS078086; 2012-2017.

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. Michael J. Fox Foundation

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

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                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Dennis W. Dickson:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. Editorial board member: Acta Neuropathologica, Brain, Brain Pathology, Neurobiology of Aging, Annals of Neurology, Neuropathology; Editor: International Journal of Clinical and Experimental Pathology, American Journal of Neurodegenerative Disease.

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. P50AG016574 (Core Leader); P50NS072187 (Center Director); P01NS084974 (Project Leader); P01AG003949 (Core Leader)

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. Society for PSP: Foundation for PSP|CBD and Related Disorders Mangurian Foundation

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Kin Mok:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. 1) non-profit The International Parkinson and Movement Disorder Society travel grant 2012 2) non-profit 14th Asian and Oceanian Congress of Neurology (AOCN) speaker honoraria 2014 3) non-profit The International Parkinson and Movement Disorder Society travel grant 2016

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. 1) ERA-Net NEURON Stipend for tuition fees Mar 2010 -Sept 2012

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. 1) Karin och Sten Morstedt CBD Solutions grant Jan 2014 - present DNA sequence analysis of corticobasal degeneration 2) Wellcome Trust Strategic Grant No. 098330/Z/12/Z 2014 -present LonDowns Consortium 3) Wellcome/MRC WT089698 Mar 2010 ? Feb 2015 Investigation into the pathogenesis and course of Parkinson's syndrome 4) Motor Neuron Disease Association grant and Intramural Research Programs of the NIH, the National Institute on Aging (Z01-AG000949-02) Amyotrophic lateral sclerosis GWAS and follow up 5) Dystonia Medical Research Foundation Grant Apr 2009 ? Apr 2011 Cervical Dystonia GWAS

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

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                1. NONE

                Legal Proceedings:

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                Niccolo E. Mencacci:
                Comment :

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                1. NONE

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                1. NONE

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. 1) MRC/Wellcome Trust 2) BRC NIHR

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

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                1. NONE

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                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

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                Lucia Schottlaender:
                Comment :

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                1. NONE

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                1. NONE

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                1. NONE

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

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                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

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                Viorica Chelban:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

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                Helen Ling:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. Reta Lila Weston Institute of Neurological Studies

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. CBD Solution Research Grant

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Sean S. O'Sullivan:
                Comment :

                Scientific Advisory Boards:

                1. Advisory board for AbbVie pharmaceuticals, Clonmel pharmaceuticals

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. Honoraria from UCB Pharmaceuticals, Eisai Pharma, AbbVie, Teva Pharmaceuticals to travel to the Movement Disorders Society annual meetings and other meetings

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. Health Service Executive, Ireland. Consultant Neurologist

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. AbbVie pharmaceuticals supporting movement disorders research study in Cork

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Nicholas W. Wood:
                Comment :

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                1. NONE

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. Ed board member Neurogenetics 2005-2014 Journal of PD associate ed 2010- Journal of neurodegenerative disease 2010- Progress in Neurology and Psychiatry 2002-2015

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. MRC- UK

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. Wellcome trust Parkinson's UK

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Bryan J. Traynor:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. (1) The Italian Football Federation (FIGC), travel expenses; (2) American Academy of Neurology, travel expenses; (3) Cold Spring Harbor Laboratories, travel expenses; (4) The Italian ALS Association (ARISLA), travel expenses; (5) Movement Disorders Society, travel expenses; (6) Wellcome Trust, travel expenses; (7) The Finnish Neurological Society, travel expenses; (8) The NorthEast ALS Consortium (NEALS), travel expenses; (9) UC Irivine, travel expenses; (10) The ALS Hope Foundation, travel expenses; (11) The ALS Association, travel expenses; (12) The American Academy of Neurology, travel expenses; (13) The Motor Neuron Association (UK), travel expenses; (14) Microsoft Research, travel expenses; (15) The Italian Neurological Society, travel expenses; (16) The University of Toronto, travel expenses; (17) The International Congress of Human Genetics, travel expenses; (18) Society for Neuroscience, travel expenses.

                Editorial Boards:

                1. Neurology, editorial board, 2011-2011 Journal of Neurology, Neurosurgery, and Psychiatry, editorial board, 2013 - ongoing - Neurobiology of Aging, editorial board, 2015 -

                Patents:

                1. I have a patent pending on the clinical testing and therapeutic intervention for the hexanucleotide repeat expansion of the C9ORF72 gene.

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. National Institutes of Health

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. (1) Merck Inc;

                Research Support, Government Entities:

                1. (1) Intramural Research Program of the NIH (where I work).

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. (1) The Myasthenia Gravis Foundation; (2) the ALS Association; (3) The Packard Center for ALS Research; (4) FIGC (The Italian Football Federation); (5) the Center for Disease Control and Prevention; (6) Microsoft Research; (7) The Italian ALS Association (ARISLA); (8) The Muscular Dystrophy Association; (9)

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Luigi Ferrucci:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. Editorial Board of Pan American Journal of Aging Research, Associate Editor of the Journal of the American Geriatrics Society, Associate Editor of the Journal of Cachexia, Sarcopenia and Muscle, Editorial Board of Geriatr?a y Gerontolog?a (Barcelona, Spain)

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Howard J. Federoff:
                Comment :

                Scientific Advisory Boards:

                1. SAB: MedGenesis, LTD; Ovid: SAB; AAHC: Board; CIRM: Board; NAI: Board

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. (1) Experimental Neurology (1999 - Present); (2) Gene Therapy Reviews (2000 - Present); (3) Gene Therapy (2000 - Present); (4) NeuroRx (2002 - Present); (5) The Open Genomics Journal (2007 - Present); (6) Libertas Academica (2008 - Present); (7) Associate Editor, Journal of Parkinson?s Disease (2010 - Present)

                Patents:

                1. Utility Patent: US 6,051,428 Issued: April 18, 2000 Title: Rapid production of autologous tumor vaccines Inventors: Y. Fong, H. J. Federoff, and J. D. Rosenblatt Utility Patent: US 6,156,306 Issued: December 5, 2000 Title: Pancreatic beta-cells for allogeneic transplantation without immunosuppression Inventors: M. Brownlee, M. Horowitz, H.J. Federoff and S. Efrat Utility Patent: US 6,252,130 Issued: June 26, 2001 Title: Production of Somatic Mosaicism in Mammals Using a Recombinatorial Substrate Inventor: H.J. Federoff Utility Patent: US 6,491,909 Issued: December 10, 2002 Title: Attenuation of rejected cells transformed with adenovirus E3 Inventors: M. Brownlee, M. Horowitz, H.J. Federoff and S. Efrat Utility Patent: 8,092,791 (WO2001089304A1) Issued: January 10, 2012 Title: Method for Producing HSV Amplicons and Uses Thereof Inventors: H.J. Federoff and W.J. Bowers Utility Patent: 8,119,118 (WO2002056828A3) Issued: February 21, 2012 Title: Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof Inventors: HJ Federoff, WJ Bowers, J Frelinger, R Willis, T Evans, S Dewhurst, KA Tolba, JD Rosenblatt Utility Patent: 20040115671 (WO2002057496A9) Issued: 6/17/04 Title: Gene Expression Profiling of Endothelium in Alzheimer?s Disease Inventors: B. Zlokovic, H. J. Federoff Provisional Patent: Converted 60/250,079 Filing Date: 11/30/00 Title: Development of Helper virus free HSV Amplicon vectors for Gene Therapy of Hematologic Malignancies Inventors: K. Tolba, H.J. Federoff, W.J. Bowers, and J. Rosenblatt Provisional Patent: Converted US 60/385,230 Filing Date: 5/31/2002 Title: Integrated HSV Amplicon Vector Inventors: H. J. Federoff and W. J. Bowers Provisional Patent: Pending US 60/356,964 Filing Date: 2/13/2002 Title: Compositions and Methods for the Treatment of Parkinson?s Disease Inventors: Howard J. Federoff and Renee M. Miller Provisional Patent: Converted US 60/359,613 Filing Date: 2/25/2002 Title: Glucocorticoid-Regulated VEGF Expression via Plasmid-based Delivery Inventors: H.J. Federoff and W. J. Bowers Provisional Patent: Pending US 60/480,112 Filing Date: 6/20/03 Title: Prevention of Treatment of Deficits that Arise in Connection of or Injuries to the Nervous System Inventors: H.J. Federoff, W.J. Bowers, V. Arvanian, and L. Mendell Provisional Patent: Pending US 60/518,474 Filing Date: 11/07/03 Title: Compositions and Methods of Treating Neurological Disorders Inventors: H. J. Federoff and W. J. Bowers Provisional Patent: Pending US 60/700,758 Filling Date: 07/22/2005 Title: Biomarkers of Neurodegenerative Disease Inventors: Paul D. Coleman, Howard J. Federoff, Kathleen Maguire-Zeiss, Timothy R. Mhyre, Roger M. Kurlan, Christopher Cox, Frederick Marshall Provisional Patent: Pending US 60/700,565 Filing Date: 7/19/2006 Title: Alpha-synuclein antibodies and methods related thereto Inventors: H.J. Federoff, K. Maguire-Zeiss, and M. Sullivan Provisional Patent: Pending US 60/941,849 Filing Date: 06/04/2007 Title: Herpes Simplex Virus Amplicon Vectors Derived From Primary Isolates Inventors: S. Dewhurst, W.J. Bowers, H.J. Federoff, J.G. Frelinger, M.C. Keefer Application No.: PCT/US2006/021806 European Provisional Patent: 06784589.1 Filing Date: 06/05/2006 Title: Herpes Virus-Based Compositions And Methods Of Use In The Prenatal And Perinatal Periods Inventors: HJ Federoff and W.J. Bowers Applicant: University of Rochester US Provisional Patent Application PCT/US12/045727; 13/543,044 Filing Date: 07/06/2012 Title: System and Method for Performing Pharmacovigilance Inventors: HJ Federoff and O Frieder Applicant: Georgetown University Utility Patent Patent 9,305,140 Filing Date: 7/16/12 Title: System and Method of Applying State of Being to Health Care Delivery Inventors: HJ Federoff, E Burger, O Frieder Applicant: Georgetown University US Provisional Patent Application PCT/US14/026583 Filing Date: 3/13/14 Title: Small Molecule LRRK2 and ERK5 inhibitors Inventors: HJ Federoff, S Shah Applicant: Georgetown University US Provisional Patent Application 61/879,553 Filing Date: 9/18/13 Title: Treating Neurodegenerative Disease with Fenofibrate and Analogs Thereof Inventors: HJ Federoff, X Su, M Polymeropoulos Applicant: Georgetown University US Provisional Patent Application 61/893,762 Filing Date: 10/21/13 Title: Biomarkers for Memory Loss PCT application No. PCT/US14/061578 entitled, ?BioMarkers for Memory Loss? filed on October 21, 2014 Inventors: HJ Federoff, ME Mapstone, MS Fiandaca, AK Cheema Applicant: Georgetown University US Provisional Patent Application 61/986,555 Filing Date: 4/30/14 Title: Metabolic and Genetic Biomarkers for Memory Loss Inventors: HJ Federoff, ME Mapstone, MS Fiandaca, AK Cheema Applicant: Georgetown University U.S. Provisional Patent application 62/002,453 Filing Date: May 23, 2014 Title: Exosomal Biomarkers for Memory Loss Inventors: HJ Federoff, ME Mapstone, MS Fiandaca U.S. Provisional Patent application 62/003,666 and 62/003,357 Filing Date: May 29, 2014 Title: Genetic Biomarkers for Memory Loss Inventors: HJ Federoff, ME Mapstone, MS Fiandaca, Y Gusev U.S. Provisional Patent application Filing Date: May 27, 2014 Title: Metabolic Biomarkers for Memory Loss Inventors: HJ Federoff, ME Mapstone, MS Fiandaca, AK Cheema U.S. Provisional Patent application Filing Date: October 16, 2014 Title: Protein Biomarkers for Memory Loss Inventors: HJ Federoff, ME Mapstone, MS Fiandaca, AK Cheema

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. (1) MedGenesis, scientific advisor; (2) Ovid, SAB member (3) AAHC, Board member (4) ASENT, Immediate past president (5) NAI, Board member

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. W81XWH-09-1-0107 (Federoff, Howard J.) 01/19/09-08/31/16 Department of Defense Validation of Peripheral Biomarkers of Traumatic Brain Injury? W81XWH-09-1-0103 (Federoff, Howard J.) 01/05/09-01/04/17 Department of Defense ?Recruitment and Sample Collection for Antecedent Biomarker Discovery in Parkinson?s Disease? NINDS intramural sponsored clinical trial ?A Phase 1 Open-Label Dose Escalation Safety Study of Convection-enhanced Delivery (CED) of Adeno-Associated Virus Encoding Glial Cell Line-Derived Neurotrophic Factor (AAV2-GDNF) in Subjects with Advanced Parkinson?s Disease.? Protocol Number: 12-N-0137 Role: Co-Investigator WX81XWH-11-49-0126 (Federoff, Howard J) 05/30/14- 04/30/17 Department of Defense ?PGC-1α Therapy for Parkinsonian Neurodegeneration? Atlantic Neurosciences Institute (Federoff, Howard J) 02/07/14-12/31/16 ?Exploratory Gene Expression Analysis of Childhood Autism? W81XWH-16-1-0148 (Federoff, Howard J) 05/02/16-05/01/18 Department of Defense ?Discovery and Validation of Peripheral Biomarkers of Traumatic Brain Injury: A Risk Factor for Parkinson?s Disease?

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. Ovid, $65,000. 125,000 options MedGenesis, 450,000 shares

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Timothy R. Mhyre:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Huw R. Morris:
                Comment :

                Scientific Advisory Boards:

                1. 1) Solvay Panel Member 2) Boerhinger-Ingelheim 3) Solvay 4) Accorda 5) Exenatide

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. 1) Travel and honoraria - Lecture - Wellcome Trust, 2012 2) Teva Movement Disorders Society 2012 3) Teva Lecture 2012 4) UCB Lecturer 2012

                Editorial Boards:

                1. 1) Editorial Board Parkinson's disease 2009-2015 2) Editorial Board Journal of Neurology

                Patents:

                1. H. R. M is a co-applicant on a patent application related to C9ORF72 - Method for diagnosing a neurodegenerative disease (PCT/GB2012/052140) pending.

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. Ipsen Fund Research Fellowship 2009-2010

                Research Support, Government Entities:

                1. Welsh Assembly Government - Research Fellowship 2009-2012 Medical Research Council (UK) 2008-2010 G0700943 Medical Research Council (UK) 2012-2015

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. Parkinson's disease society J-0804 2009-2011 Progressive Supranuclear Palsy Association 2007-2009 Motor Neuron Disease Association 2010- Motor Neuron Disease Association 2010-2014

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Günther Deuschl:
                Comment :

                Scientific Advisory Boards:

                1. Medtronic, Sapiens, Britannica, Boston Scientific

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. Medtronic, Desitin, UCB

                Editorial Boards:

                1. Movement Disorders, editor 2004-2010 Aktuelle Neurologie, co-editor 1994-now Several journals, editorial board member

                Patents:

                1. NONE

                Publishing Royalties:

                1. Thieme publishers: Referenzreihe Neurologie

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Niall Quinn:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. (1)Commercial entity, type of payment. Lecture Honorarium Teva/Lundbeck March 2015 (2)Non-profit entity, type of payment. Webinar honorarium Klinik f?r Neurologie KantonsspitalCH-9007 St.Gallen Switzerland November 2015

                Editorial Boards:

                1. (1)Journal of Parkinson's Dsease Editorial Board (2010-) (2)Journal of Movement Disorders (S.Korea)International Editorial Board(2008-) (3)Movement Disorders Clinical Practice Editorial Board,(2014-15) (4)Parkinsonism and Related Disorders Editorial Board,(2015-)

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Hakan Widner:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Alberto Albanese:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. Speaker?s honoraria from Allergan, Merz, Ipsen and Medtronic

                Editorial Boards:

                1. (1) European Journal of Neurology, Associate Editor, current; (2) Frontiers in Movement Disorders, Editor, current

                Patents:

                1. NONE

                Publishing Royalties:

                1. (1) Botulinum Toxin: Clinical Practice and Science, Saunders Elsevier, 2009

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Jon Infante:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Kailash P. Bhatia:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. Funding for travel: (1) GlaxoSmithKline, (2) Orion Corporation, (3) Ipsen, (4) Merz Pharmaceuticals, LLC 5) Sun Pharmaceuticals Ltd Speaker honoraria: (1) GlaxoSmithKline, (2) Ipsen, (3) Merz Pharmaceuticals, LLC, (4) Sun Pharmaceutical Industries Ltd.

                Editorial Boards:

                1. (1) Movement Disorders, Associate Editor (2) Therapeutic Advances in Neurological Disorders, Editorial Board 3) Co- Editor in Chief - Movement disorders Clinical Practise

                Patents:

                1. NONE

                Publishing Royalties:

                1. (1) Oxford Specialist Handbook of Parkinson?s Disease and Other Movement Disorders, Oxford University Press, 2008 2) Marsdens book of Movement disorder, Oxford Universty Press 2012 3) Lancet Neurology review article- 2012

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. Consultancy work for Allergan, Ipsen, Merz

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. 1) Wellcome Trust MRC strategic neurodegenerative disease initiative award (WT089698), (2) Parkinson's UK 3) Dystonia Coalition 4) The Bachmann-Strauss Foundation

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Werner Poewe:
                Comment :

                Scientific Advisory Boards:

                1. Werner Poewe has received consultancy and lecture fees from Abbott, Astra Zeneca, Teva, Novartis, GSK, Boehringer-Ingelheim, UCB, Orion Pharma, Abbott and Merck Serono in relation to clinical drug development programmes for PD.

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. Werner Poewe has received consultancy and lecture fees from Abbott, Astra Zeneca, Teva, Novartis, GSK, Boehringer-Ingelheim, UCB, Orion Pharma, Abbott and Merck Serono in relation to clinical drug development programmes for PD.

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. 1. Therapeutics of Parkinson's Disease and Other Movement Disorders, Hallett M, Poewe W, Wiley, 2008 2. Non-motor symptoms of Parkinson's Disease, Chaudhuri R, Poewe W, Oxford University Press, 2009 3. Parkinson-Syndrome und andere Bewegungsst?rungen Hrsg. Oertel W, Deuschl G, Poewe W, Thieme 2011

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. Werner Poewe has received consultancy and lecture fees from Abbott, Astra Zeneca, Teva, Novartis, GSK, Boehringer-Ingelheim, UCB, Orion Pharma, Abbott and Merck Serono in relation to clinical drug development programmes for PD.

                Speakers' Bureaus:

                1. Werner Poewe has received consultancy and lecture fees from Abbott, Astra Zeneca, Teva, Novartis, GSK, Boehringer-Ingelheim, UCB, Orion Pharma, Abbott and Merck Serono in relation to clinical drug development programmes for PD.

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. Michael J. Fox Foundation 1. ?Validation of Dyskinesia Rating Scales?, Goetz C, 2009 2.

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Wolfgang Oertel:
                Comment :

                Scientific Advisory Boards:

                1. (1) Boehringer Ingelheim, (2) Medtronic, (3) Merck-Sharp and Dohme, (4) Novartis, (5) UCB (6) Mundipharma (7) Teva (8) Adamas

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. (1) Boehringer Ingelheim, (2) Novartis (3) Orion-Pharma, (4) UCB (6) Teva (7) Desitin (8) Mundipharma (9) Glaxo Smith Kline (10)Abbvie

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. see point 1 and point 3

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. (1) Novartis

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. (1) Michael J Fox Foundation, (2) International Parkinson Foundation, (3) German Research Foundation (4) WH Oertel is Hertie Senior Research Professor supported by the Charitable Hertie Foundation, Frankfurt, Germany

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. (1) Roche 250 (3) Merck Darmstadt 300

                Legal Proceedings:

                1. NONE

                Günter U. Höglinger:
                Comment :

                Scientific Advisory Boards:

                1. (1) Asceneuron, (2) Abbvie, (3) Bristol-Myers Squibb, (4) Roche, (5) UCB

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. (1) Abbvie, (2) Roche, (3) UCB, (4) Movement Disorders Society

                Editorial Boards:

                1. NONE

                Patents:

                1. (1) Method for the treatment of neurodegenerative diseases. PCT/EP2015/068734.

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. (1) Sellas Life Sciences Group

                Research Support, Government Entities:

                1. (1) Bayerische Forschunsallianz, (2) German Ministry of Education and Research (BMBF), (3) German Academic Exchange Service (DAAD), (4) German Research Foundation (DFG), (5) German Center for Neurodegenerative Diseases (DZNE)

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. (1) CurePSP, (2) International Parkinson Foundation, (3) NOMIS Foundation

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Ullrich Wüllner:
                Comment :

                Scientific Advisory Boards:

                1. (1) Advisory board UCB Pharma

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. Bayer AG,travel and speaker honoraria Bristol-Myers-Squibb,travel and speaker honoraria Daiichi Sankyo Deutschland GmbH,travel and speaker honoraria UCB Pharma,travel and speaker honoraria Sanofi-Aventis Deutschland GmbH,travel and speaker honoraria Zambon GmbH, travel and speaker honoraria

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. 1)German Federal Ministry of Education and Research (BMBF) through the EpiPD (Epigenomics of Parkinson?s disease) project, under the auspices of the bilateral Epigenomics of Common and Age-related Diseases Programme (grant # 01KU1403B). 2)EU/EFPIA Innovative Medicines Initiative Joint Undertaking [Aetionomy [grant number 115568]).

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. 1) Deutsche Parkinson Vereinigung (dPV); Hans Tauber Stiftung 2) The Internationale Parkinson Fonds gGMBH

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Stefano Goldwurm:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. S. Goldwurm received grants from Italian Telethon Foundation: grant n.GTB12001B ?Parkinson Institute Biobank? (2012-17). S. Goldwurm is coordinator of the Italian consortium of the COURAGE-PD (COmprehensive Unbiased Risk factor Assessement for Genetics and Environment in PD) funded by JPND (The EU Joint Programme ? Neurodegenerative Disease Research), 2014- 17.

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Maria Teresa Pellecchia:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Joaquim Ferreira:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Eduardo Tolosa:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. honoraria as a speaker for UCB, Boeringer Ingelheim, Novartis, Abbot, Medtronic, Solvay, GSK

                Editorial Boards:

                1. Editorial advisory board member for Journal Neurological Sciencies

                Patents:

                1. Date of filing: 17.12.2015 Title: method for the sub-classification of patients suffering from parkinson disease

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. The Michael J Fox foundation for Parkinson's Disease Novartis UCB Abbot Teva

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. -Fondo de Investigaciones Sanitarias de la Seguridad Social (FISS)Principal Investigator From 2008 to 2013 - European Project for Mendelian Forms of Parkinson's Disease ( MEFOPA) PI040438 Principal Investigator from 2010 to 2012

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Bastiaan R. Bloem:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. Abbvie (speaker's fee) Zambon (speaker's fee)

                Editorial Boards:

                1. Member editorial board, Movement Disorders (until 2010) Member editorial board, Physiotherapy Canada Editor-in-chief, Tijdschrift voor Neurologie & Neurochirurgie (until 2013) Associate editor, Journal of Parkinson's Disease (since 2013)

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. Radboud University Nijmegen Medical Center

                Consultancies:

                1. ? Danone (commercial entity) Glaxo-Smith-Kline (commercial entity) UCB (commercial entity) Adamas (commercial entity) Teva (commercial entity) Zambon (commercial entity)

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. ? MyCognition

                Research Support, Government Entities:

                1. ? Grant of the Parkinson Society Canada?s National Research Program (funding for full PhF program for Eveline Pasman). Role: co-investigator (project leader: Dr. Mark Carpenter), 2014 ? Grant of Euregio (European Fund Regional Development), with co-funding by the German Parkinson Patient Foundation and the Dutch province of Gelderland Role: project leader (together with Marten Munneke), 2014

                Research Support, Academic Entities:

                1. ? Joint Programme - Neurodegenerative Disease Research (JPND) ? Radboud University Medical Centre ? Schr?dinger Stipendium

                Research Support, Foundations and Societies:

                1. (1)National Parkinson Foundation , (2)SBOH, (3)Stichting Parkinson Fonds, (4)Stichting Parkinson Nederland, (5)Fred Foundation, (6) Hersenstichting, (7) The Cure Parkinson's trust

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Olivier Rascol:
                Comment :

                Scientific Advisory Boards:

                1. AbbVie Britannia Lundbeck Merck MundiPharma Sanofi Servier Teva UCB XenoPort Zambon

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. Boehringer Ingelheim MundiPharma

                Editorial Boards:

                1. Movement Disorders

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. AbbVie Britannia Lundbeck Merck MundiPharma Sanofi Servier Teva UCB XenoPort Zambon

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. Boehringer Ingelheim Lundbeck Teva UCB

                Research Support, Government Entities:

                1. Agence Nationale de la Recherche CHU de Toulouse France-Parkinson INSERM-DHOS Recherche Clinique Translationnelle MJFox Foundation

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. France Parkinson (CoPark), MJ Fox Foundation (Simvastatine)

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Wassilios G. Meissner:
                Comment :

                Scientific Advisory Boards:

                1. Jambon France

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. Speaking fees from TEVA/Lundbeck, ORKYN; travel grants from Abbie.

                Editorial Boards:

                1. Journal of Neural Transmission, field editor neurology and translational studies

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. Speaking fees from TEVA/Lundbeck, ORKYN; travel grants from Abbie.

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. French Health Ministry, the European Community, ANR, LABEX Excellence Initiative.

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. Michael J Fox Foundation, France Parkinson, PSP-France and MSA Coalition.

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                John A. Hardy:
                Comment :

                Scientific Advisory Boards:

                1. Consulting for Eisai and Lilly on Alzheimer's and Parkinson's diseases

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. Eisai

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Tamas Revesz:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. IV International Symposium on Parkinson?s disease and movement disorders - sponsered by Boehringer-Ingelheim - honorarium Teaching visiting Turkish Neurologists Teaching visiting Swedish Neurologists ADPD Meeting 2013 - Florence

                Editorial Boards:

                1. Associate Editor: Journal of Parkinson's disease Member of Editorial Advisory Board: Neuropathology and Applied Neurobiology Associate Editor Journal of Parkinson's Disease

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. Merck Serono - Consultancy

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. Orion Pharma: Research Grant (Does Levodopa have toxic effects in Parkinson?s disease brain?) CBD Solutions: Disease progression in corticobasal degeneration

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. 1.) Alzheimer?s Research Trust (PI: T Revesz, J Holton; M Rossor; A. Lees), (ART/PG2007/2), (ART/PG2007/2); Title: Clinicopathol. correlation in frontotemporal lobar degeneration, 1/1/2008-31/12, 2011 2.) Alzheimer?s Research Trust Research Fellowship; (F Plattner ? fellow;T Revesz ? sponsor), (ART/RD2005/1), Title: Analysis of molec. mechanisms in tau hyperphosphorylation, 1/3/2006?31/8/2009 3.) European Commission, Programme Grant (LSHM-CT-2004-503039), BrainNet Europe II. Network of Excellence, one of UK Components (PI T Revesz, AJ Lees, JL Holton); 01/07/2007-30/06/2009 4.) Sarah Matheson Trust (PI: T Revesz; J Holton), (Margaret Watson Memorial Grant) Title: The role of p25 in GCI formation in multiple system atrophy; 1/1/2008?31/12/2008 5.) Sarah Matheson Trust, (J. Holton, T Revesz, H. Houlden, J. Hardy, AJ Lees), Title: The central role of oligodendroglia in the pathogenesis of multiple system atrophy, 01/03/2008 - 28/02/2011 6.) Parkinson?s Disease Society, UK (PI: T Revesz; J Holton) (PDS/4062), Titlle: Support for Parkinson?s Disease brain banking, 15/9/2004 ? 31/12/2007 7.) Parkinson's UK (Parkinson's Disease Society): Understanding pathological spread in Parkinson's disease. 2010-2013. PI: Tamas Revesz 8.) MRC/Wellcome Trust: Understanding Parkinson's disease: lessons from biology. 2010-2015. Co-applicant.

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Janice L. Holton:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. 1. Merck-Serono. Agreement to cover travel expenses to give a seminar in Geneva 8.4.2011.

                Editorial Boards:

                1. Member of the editorial board Neuropathology Applied Neurobiology 2007- present Executive Editor Neuropathology Applied Neurobiology 2012- 2014 Editor-in-Chief Neuropathology Applied Neurobiology 2014

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. University College London, full time employment.

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NONE

                Research Support, Academic Entities:

                1. 1.Alzheimer?s Research Trust. January 2008 ? December 2010 2.The Margaret Watson Memorial Trust Grant from The Sarah Matheson Trust. January 2008 ? December 2008 3. Action Medical Research November 2007 ? October 2009 4. Brain Net Europe: Support for the Queen Square Brain Bank for Neurological Disorders July 2007 ? June 2009 5.The Sarah Matheson Trust. January 2009 ? December 2011 6. Myositis Support Group June 2009 ? May 2010 and July 2015 - June 2016 7. The Multiple System Atrophy Trust. August 2012 ? July 2014 and June 2015 - January 2017 8. Michael J Fox Foundation for Parkinson?s Research December 2010 ? November 2011 July 2014-2015 9. Alzheimer?s Research UK March 2012 - February 2013 10. MSA Coalition July 2015 - June 2016 11. King Baudouin Foundation Sophia Fund May 2016-April 2018

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Thomas Gasser:
                Comment :

                Scientific Advisory Boards:

                1. (1) Joint programming in neurodegenerative diseases

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. (1) MedUpdate: speakers honoraria and funding for travel (2) Movement Disorders Society: funding for travel (3) Michael J Fox Foundation: funding for travel (4) UCB Pharma

                Editorial Boards:

                1. (1) Parkinsonism and Related Disorders, editorial board member, since 2007; (2) Movement Disorders, editorial board member; (3) Journal of Neurology, editorial board member

                Patents:

                1. (1) KASPP (LRRK2) Gene, its Production and Use for the Detection and Treatment of Neurodegenerative Diseases

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. (1) Novartis; (2) Merck-Serono; (3) Schwarz Pharma; (4) Boehringer Ingelheim; (5) Valeant Pharma

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. (1) Novartis Pharma AG

                Research Support, Government Entities:

                1. (1) ERA-Net Neuron, BMBF, 01EW0908, PI, 2009-2012; (2) MultiSyn, EU, PI 2014 - 2018 (3) Courage-PD, BMBF Joint programming, 2013 - 2017 (4) European Comission

                Research Support, Academic Entities:

                1. (1) DZNE, Helmholtz Association, PI, 2009 ff

                Research Support, Foundations and Societies:

                1. (1) Michael J Fox Foundation (2) The German Research Foundation

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Gregor K. Wenning:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. (1) Astra-Zeneca Speaker Honoraria (2) Lundbeck Speaker Honoraria

                Editorial Boards:

                1. Clinical Autonomic Research

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. (1) Astra Zeneca

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. (1) Austrian Science Foundation, FWF SFB F4414, 2015-2019

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Andrew B. Singleton:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. (1) 23andMe, travel payment

                Editorial Boards:

                1. No financial compensation, but serve on: Annals of Neurology Lancet Neurology Neurogenetics Neurodegenerative Diseases Brain Journal of Parkinson's Disease

                Patents:

                1. Patent pending for panel of markers to diagnose stroke

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. NIH Intramural funding Department of Defense, W81XWH-09-2-0128, PI, 2009-2011

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Henry Houlden:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for Travel or Speaker Honoraria:

                1. NONE

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

                Speakers' Bureaus:

                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. My laboratory is funded by: The Medical Research Council (MRC) UK, The BRT, The MDA USA, Muscular Dystrophy UK, Rosetrees Trust, The Wellcome Trust and the National Institute for Health Research (NIHR) UCLH/UCL Biomedical Research Centre.

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. My laboratory is funded by: The Dystonia Medical Research Foundation (DMRF), The Parkinson's Disease Foundation (PDF), National Organisation for Rare Disorders (NORD) and The Brain Research Trust (BRT). The National Institute for Health Research (NIHR) UCLH/UCL Biomedical Research Centre.

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

                Royalty Payments, Technology or Inventions:

                1. NONE

                Stock/Stock Options, Research Sponsor:

                1. NONE

                Stock/Stock Options, Medical Equipment & Materials:

                1. NONE

                Legal Proceedings:

                1. NONE

                Journal
                Journal ID (nlm-ta): Neurology
                Journal ID (iso-abbrev): Neurology
                Journal ID (hwp): neurology
                Journal ID (publisher-id): neur
                Journal ID (pmc): neurology
                Journal ID (publisher-id): NEUROLOGY
                Title: Neurology
                Publisher: Lippincott Williams & Wilkins (Hagerstown, MD )
                ISSN (Print): 0028-3878
                ISSN (Electronic): 1526-632X
                Publication date (Print): 11 October 2016
                Publication date PMC-release: 11 October 2016
                Volume: 87
                Issue: 15
                Pages: 1591-1598
                Affiliations
                Authors' affiliations are listed at the end of the article.
                Author notes
                Correspondence to Dr. Houlden: h.houlden@ 123456ucl.ac.uk or Dr. Scholz: sonja.scholz@ 123456nih.gov

                Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article. The Article Processing Charge was paid by Wellcome Trust.

                Coinvestigators are listed at Neurology.org.

                Article
                Publisher ID: NEUROLOGY2016719088
                DOI: 10.1212/WNL.0000000000003221
                PMC ID: 5067544
                PubMed ID: 27629089
                SO-VID: f4c646ad-4cf0-4038-9df3-133e7e491496
                Copyright © © 2016 American Academy of Neurology
                License:

                This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 17 January 2016
                Date accepted : 15 June 2016
                Categories
                Subject: 91
                Subject: 95
                Subject: 172
                Subject: Article
                Custom metadata
                OPEN-ACCESS TRUE

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