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Abstract
Individuals with Down's syndrome have a greater risk of leukaemia than the general
population, but reliable estimates of the age-specific risk are lacking and little
is known about the risk of solid tumours.
We identified 2814 individuals with Down's syndrome from the Danish Cytogenetic Register,
and linked the data to the Danish Cancer Registry. The number of person-years at risk
was 48453. Standardised incidence ratio (SIR) and 95% CI were calculated of the basis
of cancer rates specific for age and sex in the general population.
60 cases of cancer were found, with 49.8 expected (SIR 1.20 [95% CI 0.92-1.55]). Leukaemia
constituted 60% of cases of malignant disease overall and 97% of cases in children.
The SIR for leukaemia varied with age, being 56 (38-81) at age 0-4 years and 10 (4-20)
at 5-29 years. No cases of leukaemia were seen after the age of 29 years. The SIR
for acute myeloid leukaemia was 3.8 (1.7-8.4) times higher than that for acute lymphoblastic
leukaemia in children aged 0-4 years. The cumulative risk for leukaemia by the age
of 5 years was 2.1% and that by 30 years was 2.7%. Only 24 solid tumours were seen,
with 47.8 expected (0.50 [0.32-0.75]). No cases of breast cancer were found, with
7.3 expected (p=0.0007). Higher than expected numbers of testicular cancers, ovarian
cancers, and retinoblastomas were seen but were not significant. INTREPRETATION: The
occurrence of cancer in Down's syndrome is unique with a high risk of leukaemia in
children and a decreased risk of solid tumours in all age-groups. The distinctive
pattern of malignant diseases may provide clues in the search for leukaemogenic genes
and tumour-suppressor genes on chromosome 21.