Strategies towards the synthesis of calyciphylline A-type Daphniphyllum alkaloids

Abstract

The structurally unique calyciphylline A-type Daphniphyllum alkaloids have recently attracted the interest of natural product synthesis groups, due to the challenge posed by the complex structural framework. Recently, several noteworthy core syntheses were reported using a variety of novel synthetic strategies, which include intramolecular Michael addition, Pd-catalysis, cycloaddition and Mannich-type reactions.

Abstract

Covering: up to September 2013

The Daphniphyllum alkaloids are a diverse family of natural products rich in number and structural diversity that have been known for many decades. However, the structurally unique subclass of calyciphylline A-type alkaloids has only recently been discovered and is relatively unexplored. Several noteworthy core syntheses and the development of a wide range of novel synthetic strategies have been achieved. This includes strategies based on intramolecular Michael addition, Pd-catalysis, cycloaddition, and Mannich-type reactions. This review will provide an overview of these synthetic studies.