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      Clinical characteristics, systemic complications, and in-hospital outcomes for patients with COVID-19 in Latin America. LIVEN-Covid-19 study: A prospective, multicenter, multinational, cohort study

      research-article
      1 , 2 , 3 , * , , 1 , 1 , 1 , 1 , 2 , 1 , 2 , 1 , 1 , 2 , 4 , 5 , 6 , 6 , 7 , 1 , 8 , 9 , 3 , 10 , 1 , 8 , 1 , 8 , 8 , 11 , 12 , 13 , 4 , 1 , 1 , 6 , 6 , 6 , 6 , 6 , 14 , 10 , 7 , 7 , 15 , 16 , for the LIVEN-Covid-19 Investigators
      PLoS ONE
      Public Library of Science

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          Abstract

          Purpose

          The COVID-19 pandemic has spread worldwide, and almost 396 million people have been infected around the globe. Latin American countries have been deeply affected, and there is a lack of data in this regard. This study aims to identify the clinical characteristics, in-hospital outcomes, and factors associated with ICU admission due to COVID-19. Furthermore, to describe the functional status of patients at hospital discharge after the acute episode of COVID-19.

          Material and methods

          This was a prospective, multicenter, multinational observational cohort study of subjects admitted to 22 hospitals within Latin America. Data were collected prospectively. Descriptive statistics were used to characterize patients, and multivariate regression was carried out to identify factors associated with severe COVID-19.

          Results

          A total of 3008 patients were included in the study. A total of 64.3% of patients had severe COVID-19 and were admitted to the ICU. Patients admitted to the ICU had a higher mean (SD) 4C score (10 [3] vs. 7 [3)], p<0.001). The risk factors independently associated with progression to ICU admission were age, shortness of breath, and obesity. In-hospital mortality was 24.1%, whereas the ICU mortality rate was 35.1%. Most patients had equal self-care ability at discharge 43.8%; however, ICU patients had worse self-care ability at hospital discharge (25.7% [497/1934] vs. 3.7% [40/1074], p<0.001).

          Conclusions

          This study confirms that patients with SARS CoV-2 in the Latin American population had a lower mortality rate than previously reported. Systemic complications are frequent in patients admitted to the ICU due to COVID-19, as previously described in high-income countries.

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          Most cited references44

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          Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support.

          Research electronic data capture (REDCap) is a novel workflow methodology and software solution designed for rapid development and deployment of electronic data capture tools to support clinical and translational research. We present: (1) a brief description of the REDCap metadata-driven software toolset; (2) detail concerning the capture and use of study-related metadata from scientific research teams; (3) measures of impact for REDCap; (4) details concerning a consortium network of domestic and international institutions collaborating on the project; and (5) strengths and limitations of the REDCap system. REDCap is currently supporting 286 translational research projects in a growing collaborative network including 27 active partner institutions.
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            Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

            There is limited information describing the presenting characteristics and outcomes of US patients requiring hospitalization for coronavirus disease 2019 (COVID-19).
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              Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy

              In December 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) emerged in China and has spread globally, creating a pandemic. Information about the clinical characteristics of infected patients who require intensive care is limited.
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                Author and article information

                Contributors
                Role: ConceptualizationRole: Data curationRole: MethodologyRole: ValidationRole: Writing – review & editing
                Role: SupervisionRole: Writing – original draft
                Role: Writing – review & editing
                Role: Writing – review & editing
                Role: InvestigationRole: Writing – original draftRole: Writing – review & editing
                Role: Writing – original draftRole: Writing – review & editing
                Role: Writing – original draft
                Role: Supervision
                Role: Validation
                Role: Project administrationRole: Visualization
                Role: Validation
                Role: ConceptualizationRole: Validation
                Role: Data curationRole: Methodology
                Role: Conceptualization
                Role: Writing – review & editing
                Role: Validation
                Role: Supervision
                Role: Validation
                Role: Supervision
                Role: InvestigationRole: Resources
                Role: Validation
                Role: Validation
                Role: Visualization
                Role: Supervision
                Role: Supervision
                Role: Validation
                Role: Validation
                Role: Validation
                Role: Supervision
                Role: Supervision
                Role: Validation
                Role: Supervision
                Role: Validation
                Role: Supervision
                Role: Validation
                Role: Editor
                Journal
                PLoS One
                PLoS One
                plos
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                31 March 2022
                2022
                31 March 2022
                : 17
                : 3
                : e0265529
                Affiliations
                [1 ] Universidad de La Sabana, Chía, Colombiaa
                [2 ] Department of Intensive Care, Clínica Universidad de La Sabana, Chía, Colombia
                [3 ] Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
                [4 ] Department of Intensive Care, Fundación Valle del Lili, Cali, Colombia
                [5 ] TransLab- CCM, Universidad Icesi, Cali, Colombia
                [6 ] Critical Care Unit, Hospital Eugenio Espejo-Escuela de Medicina de la Universidad International, Quito, Ecuador
                [7 ] Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
                [8 ] Fundación Clínica Shaio, Bogota, Colombia
                [9 ] Critical Care Unit, Hospital Juárez de México, Ciudad de México, México City, México
                [10 ] Department of Intensive Care, Fundación Neumológica Colombiana-Fundación Cardioinfantil, Bogotá, Colombia
                [11 ] Hospital Interzonal de Agudos San Martín de La Plata, La Plata, Argentina
                [12 ] Universidad del Bosque, Bogotá, Colombia
                [13 ] Intensive Care Unit, Hospital Español, Montevideo, Uruguay
                [14 ] School of Medicine, Universidad de Federal do Rio Grande do Sul, Porto Alegre, Brazil
                [15 ] Department of Clinical Medicine, St James’s Hospital, Multidisciplinary Intensive Care Research Organization (MICRO), Dublin, Ireland
                [16 ] Hospital Clinic, IDIBAPS, Universidad de Barcelona, CIBERes, Barcelona, Spain
                University Magna Graecia of Catanzaro, ITALY
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                ¶ The complete list of LIVEN-Covid-19 Investigators is listed in the Acknowledgments.

                Author information
                https://orcid.org/0000-0003-1172-6539
                https://orcid.org/0000-0001-8344-0535
                https://orcid.org/0000-0002-2969-3408
                https://orcid.org/0000-0001-8117-0957
                https://orcid.org/0000-0001-7708-5813
                Article
                PONE-D-21-34973
                10.1371/journal.pone.0265529
                8970353
                35358238
                f5c8b839-a1af-435c-a0b7-77bc1d7582c9
                © 2022 Reyes et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 2 November 2021
                : 3 March 2022
                Page count
                Figures: 2, Tables: 3, Pages: 15
                Funding
                The author(s) received no specific funding for this work.
                Categories
                Research Article
                Medicine and Health Sciences
                Medical Conditions
                Infectious Diseases
                Viral Diseases
                Covid 19
                Medicine and Health Sciences
                Health Care
                Health Care Facilities
                Hospitals
                Intensive Care Units
                Biology and Life Sciences
                Population Biology
                Population Metrics
                Death Rates
                Medicine and Health Sciences
                Health Care
                Health Care Facilities
                Hospitals
                Biology and Life Sciences
                Physiology
                Physiological Parameters
                Body Weight
                Obesity
                People and places
                Population groupings
                Ethnicities
                Latin American people
                Medicine and Health Sciences
                Health Care
                Patients
                Medicine and Health Sciences
                Medical Conditions
                Respiratory Disorders
                Dyspnea
                Medicine and Health Sciences
                Pulmonology
                Respiratory Disorders
                Dyspnea
                Custom metadata
                All relevant data are within the paper and its Supporting information files.
                COVID-19

                Uncategorized
                Uncategorized

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