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      Spesolimab: First Approval

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      Journal: Drugs
      Publisher: Springer International Publishing

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          Abstract

          Spesolimab (spesolimab-sbzo; SPEVIGO ®) is an interleukin (IL)-36 receptor antagonist being developed by Boehringer Ingelheim for the treatment of various immune-mediated disorders. In September 2022, spesolimab was approved in the USA for the treatment of generalized pustular psoriasis (GPP) flares in adults. This article summarizes the milestones in the development of spesolimab leading to this first approval for GPP flares.

          Supplementary Information

          The online version contains supplementary material available at 10.1007/s40265-022-01801-4.

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          Inhibition of the Interleukin-36 Pathway for the Treatment of Generalized Pustular Psoriasis

          Hervé Bachelez, Siew-Eng Choon, Slaheddine Marrakchi … (2019)
          Article 0 comments Cited 116 times – based on 0 reviews     Review now
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            Trial of Spesolimab for Generalized Pustular Psoriasis

            Hervé Bachelez, Siew-Eng Choon, Slaheddine Marrakchi … (2021)
            Article 0 comments Cited 79 times – based on 0 reviews     Review now
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              An update on generalized pustular psoriasis

              Melinda Gooderham, Abby Van Voorhees, Mark G. Lebwohl (2019)
              Article 0 comments Cited 68 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Hannah A. Blair: dru@adis.com
                Journal
                Journal ID (nlm-ta): Drugs
                Journal ID (iso-abbrev): Drugs
                Title: Drugs
                Publisher: Springer International Publishing (Cham )
                ISSN (Print): 0012-6667
                ISSN (Electronic): 1179-1950
                Publication date (Electronic): 23 November 2022
                Publication date PMC-release: 23 November 2022
                Publication date (Print): 2022
                Volume: 82
                Issue: 17
                Pages: 1681-1686
                Affiliations
                GRID grid.420067.7, ISNI 0000 0004 0372 1209, Springer Nature, ; Mairangi Bay, Private Bag 65901, Auckland, 0754 New Zealand
                Article
                Publisher ID: 1801
                DOI: 10.1007/s40265-022-01801-4
                PMC ID: 9744699
                PubMed ID: 36418672
                SO-VID: f5d82e32-9ca6-48b8-8607-012726b97ebd
                Copyright © © Springer Nature 2022, corrected publication 2022
                License:

                Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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                Subject: AdisInsight Report
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                issue-copyright-statement © Springer Nature Switzerland AG 2022

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