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Inhibition of microRNA-124a attenuates non-alcoholic fatty liver disease through upregulation of adipose triglyceride lipase and the effect of liraglutide intervention.
Qian-Hua Fang
1 ,
Qi-Ling Shen
1 ,
Jin-Jin Li
1 ,
Yang Yang
1 ,
Juan-Juan Guo
1 ,
Ying Cheng
1 ,
Han-Chi Zhou
1 ,
Wen-Yan Niu
1 ,
Li-Ming Chen
1 ,
Chun-Jun Li
1 ,
Bei Sun
1
Jul 2019
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Abstract
Glucagon-like peptide-1 receptor agonists (GLP-1Ras) have been reported to prevent non-alcoholic fatty liver disease (NAFLD), but the potential mechanisms are still debated. MicroRNAs (miRNAs) play a prominent role in the field of metabolic disorders, including NAFLD. Our study was designed to further evaluate the effect of GLP-1Ra liraglutide on NAFLD in terms of miRNAs.