0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Creatine Kinase Subf orm Analysis in Hemodialysis Patients without Acute Coronary Syndromes

      , ,

      Nephron

      S. Karger AG

      Myocardial infarction, Creatine kinase, Subform analysis, Hemodialysis

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The finding of elevated levels of creatine kinase (CK) and its myocardial isoenzyme (CK MB) in the blood of patients with acute chest pain syndromes is a key factor in making the diagnosis of acute myocardial infarction. With the widespread use of thrombolytic therapy and emergency angioplasty, the ability to make a rapid and accurate diagnosis of myocardial infarction is critical. A new rapid method for analysis of the sub forms of the MB isoenzyme has been shown to be sensitive and specific for the diagnosis of myocardial infarction in the general population. Because of its rapidity it has been replacing standard analyses of total CK and CK MB in some centers in guiding the initial therapy of patients with chest pain. Levels of CK MB can be abnormally elevated in hemodialysis patients even in the absence of acute myocardial necrosis. This study was undertaken in order to determine if subform analysis of the MB isoenzyme could similarly be abnormal in hemodialysis patients without acute coronary syndromes. CK MB subforms were analyzed in 52 patients without any recent cardiac symptoms who came into the dialysis unit for a routine hemodialysis treatment. We then applied the same criteria for the diagnosis of an acute myocardial infarction as would be used clinically. In this population, the subform analysis was surprisingly consistent with myocardial infarction in approximately 29% of the patients. Thus, subform analysis appears likely to result in an erroneous diagnosis of acute myocardial infarction in patients on hemodialysis.

          Related collections

          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1997
          1997
          23 December 2008
          : 76
          : 3
          : 296-299
          Affiliations
          Department of Medicine, St. John’s-Queens Hospital, Elmhurst, N.Y., USA
          Article
          190194 Nephron 1997;76:296–299
          10.1159/000190194
          9226229
          © 1997 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Original Paper

          Comments

          Comment on this article