Arterial Blood Pressure and the Renin-Angiotensin-Aldosterone System during Postural Changes in Hypertensive Patients with Unilateral Renal Mobility

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Abstract

Unilateral renal mobility was identified in 27 out of 100 essential hypertensive patients by examination of renal scintiphotos. The pattern of response to postural changes of blood pressure (BP), plasma renin activity (PRA) and plasma aldosterone concentration (PAC) was investigated in 11 patients with renal mobility and without treatment and compared with that of an age- and sex-matched group of untreated hypertensives without renal mobility. The patients with renal mobility had higher BP levels (X ± SD mm Hg: supine 185 ± 39/112 ± 18 vs. 149 ± 18/97 ± 14; upright 167 ± 38/108 ± 17 vs. 144 ± 7/93 ± 10; p < 0.05). Significant correlations were obtained in the patients with renal mobility (but not in those without renal mobility) between upright PRA and PAC (p < 0.001), their postural variations (p < 0.01) and between upright PRA (and PAC) and BP levels (p < 0.05). The high prevalence of renal mobility in hypertension and the relationship observed between the activated renin-angiotensin-aldosterone system and BP in this condition suggest the importance of searching for unilateral renal mobility when examining the renin-angiotensin-aldosterone system in hypertensive patients, particularly during postural manoeuvres.

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Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1985

Publication date (Print): 1985

Publication date (Electronic): 04 December 2008

Volume: 40

Issue: 1

Pages: 104-107

Affiliations

^aCNR Clinical Physiology Istitute and ^bIstituto di Patologia Medica I, University of Pisa, Italy

Article

Publisher ID: 183439 Other ID: Nephron 1985;40:104–107

DOI: 10.1159/000183439

PubMed ID: 4000328

SO-VID: f78977e3-8719-476b-8068-6526076fc593

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 27 April 1984

Page count

Pages: 4

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