Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts.

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Abstract

IBS shows genetic predisposition, but adequately powered gene-hunting efforts have been scarce so far. We sought to identify true IBS genetic risk factors by means of genome-wide association (GWA) and independent replication studies.

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Journal ID (iso-abbrev): Gut

Title: Gut

ISSN (Electronic): 1468-3288

ISSN (Print): 0017-5749

Publication date (Electronic): Nov 2015

Volume: 64

Issue: 11

Affiliations

[1 ] Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.

[2 ] Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

[3 ] Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany.

[4 ] Department of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

[5 ] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

[6 ] Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.

[7 ] Faculty of Medical and Human Sciences, Institute of Inflammation and Repair, University of Manchester, Manchester, UK Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA.

[8 ] Laboratory of Biology, School of Medicine, University of Athens, Athens, Greece.

[9 ] Academic Department of Gastroenterology, School of Medicine, University of Athens, Athens, Greece.

[10 ] Molecular Epidemiology Group, German Cancer Research Centre (DKFZ) Heidelberg, Heidelberg, Germany Division of Molecular Biology of Breast Cancer, Department of Gynaecology and Obstetrics, University Women's Clinic, University Heidelberg, Heidelberg, Germany.

[11 ] Gastroenterology Unit, Department of Gastroenterology, University of Pisa, Pisa, Italy.

[12 ] Division of Pharmacology and Chemotherapy, Department of Clinical and Experimental Medicine University of Pisa, Pisa, Italy.

[13 ] Department of Medical and Surgical Sciences, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy.

[14 ] Department of Medicine, Umeå, University, Umeå, Sweden.

[15 ] Division of Gastroenterology, Institution of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

[16 ] Department of Clinical Sciences, Skånes University Hospital, Malmoe, Sweden.

[17 ] Department of Internal Medicine & Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

[18 ] Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden Department of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

[19 ] Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden Stress Research Institute, Stockholm University, Stockholm, Sweden.

[20 ] Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

[21 ] Translational Research Center for Gastrointestinal Disorders, Leuven University, Leuven, Belgium.

[22 ] Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota, USA.

Article

Publisher Item ID: gutjnl-2014-307997

DOI: 10.1136/gutjnl-2014-307997

PubMed ID: 25248455

SO-VID: f87e7cd5-d86f-4ff9-a301-46f76a42c009

History

Keywords: GENE EXPRESSION,GENETIC POLYMORPHISMS,GENETICS,IRRITABLE BOWEL SYNDROME

Data availability:

Keywords: GENE EXPRESSION, GENETIC POLYMORPHISMS, GENETICS, IRRITABLE BOWEL SYNDROME

Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts.

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