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      Endocrine Function of the Pancreas and Gastrin Secretion in Patients with a Kidney Transplant 1

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          In 24 patients with a kidney transplant and in 10 healthy subjects the test meal response of immunoreactive insulin (IRI), glucagon (IR-G), pancreatic polypeptide (IR-PP) and gastrin (IR-Ga) was studied. Patients with a kidney transplant showed significantly elevated basal plasma glucagon levels but normal levels of plasma IRI, IR-PP and IR-Ga. After administration of a test meal a significantly suppressed response of IRI, IR-PP and IR-Ga secretion was observed both in the patients treated with azathioprine as well as those treated with ciclosporin. In patients of the ciclosporin group the compromised response of IR-Ga and IRI secretion was significantly more marked than in subjects in the azathioprine group. From the results obtained in this paper it follows that the type of immunosuppressive drugs (azathioprine or ciclosporin) seems to be of minor importance in the pathogenesis of the described endocrine abnormalities.

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          Author and article information

          S. Karger AG
          10 December 2008
          : 54
          : 2
          : 144-147
          aDepartment of Nephrology, bDepartment of Surgery and cDepartment of Urology, Silesian School of Medicine, Katowice, Poland
          185835 Nephron 1990;54:144–147
          © 1990 S. Karger AG, Basel

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          Page count
          Pages: 4
          Original Paper

          Cardiovascular Medicine, Nephrology

          Pancreatic polypeptide, Insulin, Gastrin, Kidney transplant, Glucagon


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