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      Demographic and therapeutic determinants of pain reactivity in very low birth weight neonates at 32 Weeks' postconceptional Age.

      Pediatrics
      Blood Specimen Collection, adverse effects, Cohort Studies, Dexamethasone, administration & dosage, Electrocardiography, Facial Expression, Female, Fentanyl, Heart Rate, Humans, Indomethacin, Infant, Infant, Newborn, Infant, Very Low Birth Weight, Male, Monitoring, Physiologic, Morphine, Pain, drug therapy, etiology, physiopathology, Pain Measurement, Pain Threshold, Pancuronium, Prospective Studies

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          Abstract

          Management of pain in very low birth weight infants is limited by a lack of empiric knowledge about the multiple determinants of biobehavioral reactivity in infants receiving neonatal intensive care. To examine relationship of early neonatal factors and previous medication exposure to subsequent biobehavioral reactivity to acute pain of blood collection. Prospective cohort study. Methods. One hundred thirty-six very low birth weight (

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