Research progress for the interaction of child abuse and monoamine oxidase A gene on antisocial behavior among adolescents

Abstract

Antisocial behavior among adolescents caused a severe burden on individuals, families and society, which has aroused a global concern. At present, the association of child abuse and monoamine oxidase A gene with antisocial behavior has been confirmed in most studies. However, there was a controversy about the interaction of child abuse and monoamine oxidase A gene on antisocial behavior. This study aimed to review latest findings and mechanisms of the interaction of child abuse and monoamine oxidase A gene on antisocial behavior among adolescents. The result showed that the child abuse interacted with monoamine oxidase A gene in antisocial behavior by influencing the specific neural circuits in the brain and changing the function of mood regulation, etc. Additionally, this study analyzed potential reasons for the inconsistency of current study findings, and identified the directions for future research. Moreover, this review was to provide a scientific basis for the prevention and control of adolescent antisocial behavior.

Abstract

【摘要】 青少年反社会行为给个人健康、家庭和社会都带来沉重的负担, 引起了公众的广泛关注。目前, 大多数研究已证 实童年期虐待、单胺氧化酶 A 基因与反社会行为之间存在关联。然而, 关于童年期虐待与单胺氧化酶 A 基因交互作用与 反社会行为之间的关联性尚存在争议。本文旨在对童年期虐待与单胺氧化酶 A 基因交互作用与青少年反社会行为的最 新研究成果及其可能的作用机制进行综述, 发现童年期虐待与单胺氧化酶 A 基因可能通过影响大脑中特定的神经环路、 改变情绪调节功能等交互作用于反社会行为。此外, 本综述剖析了当前研究结果不一致的可能原因, 为今后研究指明方 向, 也为青少年反社会行为的预防控制提供科学依据。