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      Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.

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          Abstract

          The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          0036-8075
          0036-8075
          Apr 06 2001
          : 292
          : 5514
          Affiliations
          [1 ] Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK.
          Article
          292/5514/104
          10.1126/science.1057991
          11292874
          fad82ea9-0fa6-47a0-93bd-990fde5b5e7a
          History

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