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      Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.

      Science (New York, N.Y.)

      Aging, physiology, Alleles, Animals, Body Constitution, Carrier Proteins, genetics, metabolism, Crosses, Genetic, Drosophila Proteins, Drosophila melanogaster, Female, Fertility, Genes, Insect, Heterozygote, Hot Temperature, Insect Proteins, Insulin, Insulin Receptor Substrate Proteins, Intracellular Signaling Peptides and Proteins, Longevity, Male, Mutation, Oxidative Stress, Protein-Tyrosine Kinases, Receptor Protein-Tyrosine Kinases, Receptor, Insulin, Reproduction, Signal Transduction, Somatomedins, Starvation, Superoxide Dismutase

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          Abstract

          The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.

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          Journal
          11292874
          10.1126/science.1057991

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