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      Amines as key building blocks in Pd-assisted multicomponent processes

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          Summary

          In the last few years, palladium-mediated three-component synthesis has emerged as an important synthetic methodology to gain access to nitrogen-containing structures. The latest developments in this area are discussed in this review.

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          Most cited references43

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          Synthesis and functionalization of indoles through palladium-catalyzed reactions.

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            Palladium-catalyzed aminosulfonylation of aryl halides.

            The palladium-catalyzed three-component coupling of aryl iodides, sulfur dioxide, and hydrazines to deliver aryl N-aminosulfonamides is described. The colorless crystalline solid DABCO·(SO(2))(2) was used as a convenient source of sulfur dioxide. The reaction tolerates significant variation of both the aryl iodide and hydrazine coupling partners.
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              One-pot construction of pyrazoles and isoxazoles with palladium-catalyzed four-component coupling.

              [reaction: see text] Four-component coupling of a terminal alkyne, hydrazine (hydroxylamine), carbon monoxide, and an aryl iodide furnishes pyrazole or isoxazole derivatives in the presence of a palladium catalyst. The reaction proceeds at room temperature and an ambient pressure of carbon monoxide in an aqueous solvent system.
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                Author and article information

                Contributors
                Role: Guest Editor
                Journal
                Beilstein J Org Chem
                Beilstein Journal of Organic Chemistry
                Beilstein-Institut (Trakehner Str. 7-9, 60487 Frankfurt am Main, Germany )
                1860-5397
                2011
                10 October 2011
                : 7
                : 1387-1406
                Affiliations
                [1 ]ICBMS, Institut de Chimie et Biochimie Moléculaire et Supramoléculaire, CNRS UMR 5246, Université Lyon 1, ESCPE Lyon. 43, Bd du 11 Novembre 1918, 69622, Villeurbanne, France
                Article
                10.3762/bjoc.7.163
                3201053
                22043250
                fb5b8d94-9bb8-4a59-82ad-0755d4ea9f19
                Copyright © 2011, Bouyssi et al; licensee Beilstein-Institut.

                This is an Open Access article under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: ( http://www.beilstein-journals.org/bjoc)

                History
                : 20 May 2011
                : 14 September 2011
                Categories
                Review
                Chemistry
                Organic Chemistry

                Organic & Biomolecular chemistry
                amines,multicomponent reactions,palladium
                Organic & Biomolecular chemistry
                amines, multicomponent reactions, palladium

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