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Summary
In the last few years, palladium-mediated three-component synthesis has emerged as
an important synthetic methodology to gain access to nitrogen-containing structures.
The latest developments in this area are discussed in this review.
The palladium-catalyzed three-component coupling of aryl iodides, sulfur dioxide, and hydrazines to deliver aryl N-aminosulfonamides is described. The colorless crystalline solid DABCO·(SO(2))(2) was used as a convenient source of sulfur dioxide. The reaction tolerates significant variation of both the aryl iodide and hydrazine coupling partners.
[reaction: see text] Four-component coupling of a terminal alkyne, hydrazine (hydroxylamine), carbon monoxide, and an aryl iodide furnishes pyrazole or isoxazole derivatives in the presence of a palladium catalyst. The reaction proceeds at room temperature and an ambient pressure of carbon monoxide in an aqueous solvent system.
Publisher:
Beilstein-Institut
(Trakehner Str. 7-9, 60487 Frankfurt am Main, Germany
)
ISSN
(Electronic):
1860-5397
Publication date Collection: 2011
Publication date
(Electronic):
10
October
2011
Volume: 7
Pages: 1387-1406
Affiliations
[1
]ICBMS, Institut de Chimie et Biochimie Moléculaire et Supramoléculaire, CNRS UMR 5246,
Université Lyon 1, ESCPE Lyon. 43, Bd du 11 Novembre 1918, 69622, Villeurbanne, France
This is an Open Access article under the terms of the Creative Commons Attribution
License (
http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided
the original work is properly cited.