Decreased expression of TRAAK channels in Hirschsprung&apos;s disease: a possible cause of postoperative dysmotility.

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Abstract

Potassium (K+) channels with a two-pore domain (K2P) are a large family of hyperpolarising ion channels which play a key role in cell excitability. This family comprises three members: TREK-1, TREK-2 and TRAAK. TRAAK channels have previously been reported to be expressed in murine enteric ganglia. To date, no data exist regarding TRAAK channel expression in the human colon. Thus, we designed this study to investigate TRAAK gene expression in the normal human colon and in Hirschsprung's disease (HSCR).

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Author and article information

Journal

Journal ID (iso-abbrev): Pediatr Surg Int

Title: Pediatric surgery international

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1437-9813

ISSN (Print): 0179-0358

Publication date (Electronic): Dec 2019

Volume: 35

Issue: 12

Affiliations

[1 ] National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin 12, Ireland.

[2 ] National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin 12, Ireland. prem.puri@ncrc.ie.

Article

Publisher Item ID: 10.1007/s00383-019-04572-4

DOI: 10.1007/s00383-019-04572-4

PubMed ID: 31542828

SO-VID: fb8868d0-cd61-4bc1-8ac4-93620ddc927e

History

Keywords: TRAAK channels,Aganglionosis,Hirschsprung’s disease

Data availability:

Keywords: TRAAK channels, Aganglionosis, Hirschsprung’s disease

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Decreased expression of TRAAK channels in Hirschsprung's disease: a possible cause of postoperative dysmotility.

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