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      Secondhand Tobacco Smoke Exposure in Open and Semi-Open Settings: A Systematic Review

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          Abstract

          Background: Some countries have recently extended smoke-free policies to particular outdoor settings; however, there is controversy regarding whether this is scientifically and ethically justifiable.

          Objectives: The objective of the present study was to review research on secondhand smoke (SHS) exposure in outdoor settings.

          Data sources: We conducted different searches in PubMed for the period prior to September 2012. We checked the references of the identified papers, and conducted a similar search in Google Scholar.

          Study selection: Our search terms included combinations of “secondhand smoke,” “environmental tobacco smoke,” “passive smoking” OR “tobacco smoke pollution” AND “outdoors” AND “PM” (particulate matter), “PM 2.5” (PM with diameter ≤ 2.5 µm), “respirable suspended particles,” “particulate matter,” “nicotine,” “CO” (carbon monoxide), “cotinine,” “marker,” “biomarker” OR “airborne marker.” In total, 18 articles and reports met the inclusion criteria.

          Results: Almost all studies used PM 2.5 concentration as an SHS marker. Mean PM 2.5 concentrations reported for outdoor smoking areas when smokers were present ranged from 8.32 to 124 µg/m 3 at hospitality venues, and 4.60 to 17.80 µg/m 3 at other locations. Mean PM 2.5 concentrations in smoke-free indoor settings near outdoor smoking areas ranged from 4 to 120.51 µg/m 3. SHS levels increased when smokers were present, and outdoor and indoor SHS levels were related. Most studies reported a positive association between SHS measures and smoker density, enclosure of outdoor locations, wind conditions, and proximity to smokers.

          Conclusions: The available evidence indicates high SHS levels at some outdoor smoking areas and at adjacent smoke-free indoor areas. Further research and standardization of methodology is needed to determine whether smoke-free legislation should be extended to outdoor settings.

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          Most cited references41

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          Tobacco smoke and involuntary smoking.

          (2004)
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            Biomarkers of environmental tobacco smoke exposure.

            Biomarkers are desirable for quantitating human exposure to environmental tobacco smoke (ETS) and for predicting potential health risks for exposed individuals. A number of biomarkers of ETS have been proposed. At present cotinine, measured in blood, saliva, or urine, appears to be the most specific and the most sensitive biomarker. In nonsmokers with significant exposure to ETS, cotinine levels in the body are derived primarily from tobacco smoke, can be measured with extremely high sensitivity, and reflect exposure to a variety of types of cigarettes independent of machine-determined yield. Under conditions of sustained exposure to ETS (i.e., over hours or days), cotinine levels reflect exposure to other components of ETS. Supporting the validity of cotinine as a biomarker, cotinine levels have been positively correlated to the risks of some ETS-related health complications in children who are not cigarette smokers. Images Figure 1
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              Acute exposure to environmental tobacco smoke and heart rate variability.

              Environmental tobacco smoke (ETS) has been associated with cardiovascular mortality. Pathophysiologic pathways leading from ETS exposure to cardiopulmonary disease are still being explored. Reduced cardiac autonomic function, as measured by heart rate variability (HRV), has been associated with cardiac vulnerability and may represent an important pathophysiologic mechanism linking ETS and risk of cardiac mortality. In this study we evaluated acute ETS exposure in a commercial airport with changes in HRV in 16 adult nonsmokers. We conducted ambulatory electrocardiographic (ECG) monitoring for 8-hr periods while participants alternated 2 hr in nonsmoking and smoking areas. Nicotine and respirable suspended particle concentrations and participants' blood oxygen saturation were also monitored. We calculated time and frequency domain measures of HRV for periods in and out of the smoking area, and we evaluated associations with ETS using comparative statistics and regression modeling. ETS exposure was negatively associated with all measures of HRV. During exposure periods, we observed an average decrement of approximately 12% in the standard deviation of all normal-to-normal heart beat intervals (an estimate of overall HRV). ETS exposures were not associated with mean heart rate or blood oxygen saturation. Altered cardiac autonomic function, assessed by decrements in HRV, is associated with acute exposure to ETS and may be part of the pathophysiologic mechanisms linking ETS exposure and increased cardiac vulnerability.
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                Author and article information

                Journal
                Environ Health Perspect
                Environ. Health Perspect
                EHP
                Environmental Health Perspectives
                National Institute of Environmental Health Sciences
                0091-6765
                1552-9924
                07 May 2013
                July 2013
                : 121
                : 7
                : 766-773
                Affiliations
                [1 ]Tobacco Control Unit, Cancer Control and Prevention Programme, Institut Català d’Oncologia-ICO, L’Hospitalet de Llobregat, Barcelona, Spain
                [2 ]Cancer Control and Prevention Group, Institut d’Investigació Biomèdica de Bellvitge-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain
                [3 ]Department of Clinical Sciences, School of Medicine, Universitat de Barcelona, L’Hospitalet del Llobregat, Barcelona, Spain
                [4 ]Agència de Salut Pública de Barcelona, Barcelona, Spain
                [5 ]Institut d’Investigació Biomèdica-IBB Sant Pau, Barcelona, Spain
                [6 ]Department of Experimental and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain
                Author notes
                Address correspondence to E. Fernández, Tobacco Control Unit, Institut Català d’Oncologia, Av Gran Via 199-201, 08908 L’Hospitalet de Llobregat, Barcelona, Spain. Telephone: 34 932 607 345. E-mail: efernandez@ 123456iconcologia.net
                [*]

                M. Nebot, a leader in design and evaluation of public health interventions and in tobacco control research, died 18 October 2012.

                Article
                ehp.1205806
                10.1289/ehp.1205806
                3701994
                23651671
                fbaf0b0a-2497-4ec5-be64-ca5a1faf0a37
                Copyright @ 2013

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, properly cited.

                History
                : 23 July 2012
                : 01 May 2013
                Categories
                Review

                Public health
                exposure markers,outdoor tobacco smoke,particulate matter,passive smoking,secondhand smoke,smoking ban,tobacco smoke pollution

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