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      Localization by Immunoelectron Microscopy of Schistosoma mansoni Antigens in the Glomerulus of the Hamster (Mesocricetus auratus) Kidney


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          Adult worm antigen (AWA) and soluble egg antigen (SEA) were localized ultrastructurally by immunoelectron microscopy using two monoclonal antibodies in the glomeruli of hamsters infected with Schistosoma mansoni cercariae or injected with S. mansoni eggs. AWA was detected in all cercaria-infected groups from the 30th day on and was present mainly in cytoplasm of mesangial cells, mesangial matrix, and glomerular basement membrane, either as isolated gold particles or in small electron-dense deposits of probable immune origin. AWA was encountered also on the inner side of the glomerular basal membrane, close to endothelial cells, and in the foot processes of the glomerular epithelial cells. SEA was detected at similar sites, apparently in lesser amounts, in uninfected hamsters inoculated with S. mansoni eggs into the jugular vein. Schistosomal antigens are apparently processed mainly by mesangial cells which are considered to be critical in the pathogenesis of S. mansoni associated glomerulopathy. Mesangioproliferative glomerulonephritis, immunoglobulin (IgG and IgM), and C<sub>3</sub> deposits were observed in hamsters in which AWA and SEA were visualized. During early phases of the infection and in hamsters in which granulomatous pneumonitis was induced by S. mansoni eggs, glomeruli were unchanged or showed a slight mesangial proliferation. Our findings suggests that egg antigens also contribute to the pathogenesis of experimental glomerulopathy in the hamster.

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          A modified gel filtration technique producing an unusual exclusion volume of IgM: a simple way of preparing monoclonal IgM


            Author and article information

            Nephron Exp Nephrol
            Cardiorenal Medicine
            S. Karger AG
            August 1998
            15 July 1998
            : 6
            : 4
            : 368-376
            a Institute of Tropical Medicine, São Paulo University Medical School, and b São Paulo Federal University Medical School, Departments of Microbiology, Immunology, and Parasitology, São Paulo, Brazil
            20544 Exp Nephrol 1998;6:368–376
            © 1998 S. Karger AG, Basel

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            Page count
            Pages: 9
            Self URI (application/pdf): https://www.karger.com/Article/Pdf/20544
            Self URI (text/html): https://www.karger.com/Article/FullText/20544
            Self URI (journal page): https://www.karger.com/SubjectArea/Nephrology
            Original Paper

            Cardiovascular Medicine,Nephrology
            Immunoelectron microscopy,<italic>Schistosoma mansoni</italic> antigens,Hamster schistosomal nephropathy


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