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      Activities of taurolidine in vitro and in experimental enterococcal endocarditis.

      Antimicrobial Agents and Chemotherapy

      Animals, Anti-Bacterial Agents, pharmacology, Endocarditis, Bacterial, drug therapy, Oxacillin, Penicillin Resistance, Penicillins, Staphylococcus, drug effects, Stenotrophomonas maltophilia, Taurine, analogs & derivatives, Thiadiazines

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          Abstract

          In vitro, the antimicrobial agent taurolidine inhibited virtually all of the bacteria tested, including vancomycin-resistant enterococci, oxacillin-resistant staphylococci, and Stenotrophomonas maltophilia, at concentrations between 250 and 2,000 microg/ml. Taurolidine was not effective in experimental endocarditis. While it appears unlikely that this antimicrobial would be useful for systemic therapy, its bactericidal activity and the resistance rates found (<10(-9)) are favorable indicators for its possible development for topical use.

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          10817739
          89943

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