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Abstract
Three peptides derived from the posttranslational processing of proglucagon have been
isolated from the pancreas of the elasmobranch fish, Scyliorhinus canicula (European
common dogfish). The peptide HSEGT FTSDY SKYMD NRRAK DFVQW LMST represents the 29
amino acid residue form of glucagon previously identified in dogfish intestine. A
second component with 33 amino acid residues represents glucagon extended from its
COOH-terminal region by -KRNG. The peptide HAEGT YTSDV DSLSD YFKAK RFVDS LKSY represents
glucagon-like peptide (GLP). The primary structures of the GLPs from mammals have
strongly conserved but a comparison of the amino acid sequences of known GLPs from
different classes of fish shows that the structure of the peptide has been very poorly
conserved in lower vertebrates. Only three residues (Ala2, Asp9, and Leu26) are found
in the same position in all fish GLPs. A similar comparison of the primary structures
of glucagons from the same species shows 13 amino acid residues in common.