0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Simultaneous Evaluation of the Doppler-DerivedTransmitral Flow Velocity Waveform and Left Ventricular Isovolumic Relaxation Time in Patients with Coronary Artery Disease

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          We studied the usefulness of simultaneous evaluation of the Doppler-derived transmitral flow velocity waveform and left ventricular isovolumic relaxation time (IRT) in patients with coronary artery disease (CAD). Subjects consisted of 26 healthy volunteers, 54 patients with prior myocardial infarction (MI), and 27 patients with CAD but without prior MI. IRT was measured as the time from the beginning of the aortic valve closure sound to the onset of trans-mitral flow. Peak filling velocity during early diastole (E-wave velocity), peak filling velocity during atrial contraction (A-wave velocity), and IRT were compared among the three groups. No significant difference in A-wave velocity was found among these groups. Whereas E-wave velocity was significantly lower and IRT was significantly longer in patients with CAD but without prior MI than in healthy subjects, no significant differences in E-wave velocity or IRT were observed between patients with prior MI and healthy subjects. We then divided the patients with prior MI into two subgroups, one consisting of 45 patients with mean pulmonary capillary wedge pressure (mPCWP) < 16 mm Hg and the other consisting of 9 patients with mPCWP > 16 mm Hg. There was no significant difference in A-wave velocity between the two subgroups and healthy subjects. E-wave velocity was significantly lower in patients with MI and lower mPCWP than in healthy subjects, however, no significant difference in E-wave velocity was found between the patients with MI and higher mPCWP and the healthy subjects. On the other hand, IRT was significantly longer in those with lower mPCWP and significantly shorter in those with higher mPCWP than in healthy subjects. In conclusion, normal transmitral flow velocity waveform with short IRT suggests a ‘pseudonormaΓ pattern due to elevated mPCWP in patients with CAD.

          Related collections

          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1996
          1996
          19 November 2008
          : 87
          : 6
          : 560-565
          Affiliations
          Third Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan
          Article
          177154 Cardiology 1996;87:560–565
          10.1159/000177154
          8904686
          © 1996 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Noninvasive and Diagnostic Cardiology

          Comments

          Comment on this article