Ensuring good usability can be seen as the key success factor in our whole digital world: technology must support people. In particular, Medicine and Healthcare are currently subject to exceedingly rapid technological change. Vital areas for the economy include health of nations; medicine and healthcare entangles everybody, accordingly the role of usability is of increasing importance. Consequently, Medicine and Healthcare are a great challenge for Human-Computer Interaction (HCI) research; however, it is of vital importance that the findings are integrated into engineering at a systemic level. Information Processing, in particular its potential effectiveness in modern Health Services and the optimization of processes and operational sequences, is of increasing interest, but we need to ensure that we engineer effective solutions as well as understanding the stakeholders and the issues they can and do encounter. It is particularly important for Medical Information Systems (e.g. Hospital Information Systems and Decision Support Systems) to be designed from the perspective of the end users, especially given that this is a diverse set of people.