Recent years have witnessed a rise in the quantity of waste glass due to a rise in industrialization and a rapid improvement in living standards, which can lead to the depletion of natural resources and pollution of the environment. The potential use of waste recycled glass as sand replacement in concrete was examined, response surface methodology (RSM) was applied to optimize process parameters. A randomized custom design was employed to determine the effect of glass-sand (G-S) replacement parameters on the developed concrete compressive strength. The regression analysis revealed an excellent fit between the experimental data and the model, as measured by the coefficient of determination (R 2) of 0.9094, Adjusted R 2 of 0.8591 and a model F-value of 18.07. The optimum percentage combination was 10% of glass with 90% of sand, as recorded from the desirability function. At the optimal combination, the compressive strength of concrete was 30.5 MPa. The experimental findings ascertain that the substitution of sand with glass aggregate can be a suitable alternative to natural sand and can effectively be applied industrially. The local waste glass materials have demonstrated that they can effectively substitute for a portion of traditional materials and mitigate the environmental pollution associated with solid waste disposal.