Urinary F2-isoprostanes are poor prognostic indicators for the development of bronchopulmonary dysplasia.

Reuter, S D; O'Donovan, D J; Hegemier, S E; Smith, E O; Heird, W C; Fernandes, C J

doi:10.1038/sj.jp.7211684

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Urinary F2-isoprostanes are poor prognostic indicators for the development of bronchopulmonary dysplasia.

Author(s): S Reuter, D J O'Donovan, S Hegemier, E Smith, W C Heird, C J Fernandes

Publication date: 2007-05-01

Journal: Journal of perinatology : official journal of the California Perinatal Association

Publisher: Springer Nature

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Abstract

Oxygen toxicity is thought to contribute to the development of bronchopulmonary dysplasia (BPD). Oxidant injury leads to formation of F(2)-isoprostanes (F(2)-IsoP). We hypothesized that urinary excretion of the stable metabolite of F(2)-IsoP, 8-iso-PGF(2alpha), would be higher in infants who develop BPD than those who did not.

Urinary F2-isoprostanes are poor prognostic indicators for the development of bronchopulmonary dysplasia.

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Pneumonia, sex, and the environment

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