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      Bacterial quorum sensing: the progress and promise of an emerging research area

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          Preface

          This review highlights how we can build upon the relatively new and rapidly developing field of bacterial communication or quorum sensing (QS). We now have a depth of knowledge about how bacteria use QS signals to communicate with each other and coordinate activities. There have been extraordinary advances in QS genetics, genomics, biochemistry, and diversity of signaling systems. We are beginning to understand the connections between QS and bacterial sociality. This foundation places us at the precipice of a new era where researchers can advance towards development of new medicines to treat devastating infectious diseases, and in parallel use bacteria to understand the biology of sociality.

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          Most cited references90

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          Social evolution theory for microorganisms.

          Stuart West, Ashleigh S. Griffin, Andy Gardner … (2006)
          Microorganisms communicate and cooperate to perform a wide range of multicellular behaviours, such as dispersal, nutrient acquisition, biofilm formation and quorum sensing. Microbiologists are rapidly gaining a greater understanding of the molecular mechanisms involved in these behaviours, and the underlying genetic regulation. Such behaviours are also interesting from the perspective of social evolution - why do microorganisms engage in these behaviours given that cooperative individuals can be exploited by selfish cheaters, who gain the benefit of cooperation without paying their share of the cost? There is great potential for interdisciplinary research in this fledgling field of sociomicrobiology, but a limiting factor is the lack of effective communication of social evolution theory to microbiologists. Here, we provide a conceptual overview of the different mechanisms through which cooperative behaviours can be stabilized, emphasizing the aspects most relevant to microorganisms, the novel problems that microorganisms pose and the new insights that can be gained from applying evolutionary theory to microorganisms.
          Article 0 comments Cited 373 times – based on 0 reviews     Review now
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            Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators.

            W Fuqua, S Winans, E Greenberg (1994)
            Article 0 comments Cited 337 times – based on 0 reviews     Review now
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              Cooperation and conflict in quorum-sensing bacterial populations.

              Stephen P. Diggle, Ashleigh S. Griffin, Genevieve Campbell … (2007)
              It has been suggested that bacterial cells communicate by releasing and sensing small diffusible signal molecules in a process commonly known as quorum sensing (QS). It is generally assumed that QS is used to coordinate cooperative behaviours at the population level. However, evolutionary theory predicts that individuals who communicate and cooperate can be exploited. Here we examine the social evolution of QS experimentally in the opportunistic pathogen Pseudomonas aeruginosa, and show that although QS can provide a benefit at the group level, exploitative individuals can avoid the cost of producing the QS signal or of performing the cooperative behaviour that is coordinated by QS, and can therefore spread. We also show that a solution to the problem of exploitation is kin selection, if interacting bacterial cells tend to be close relatives. These results show that the problem of exploitation, which has been the focus of considerable attention in animal communication, also arises in bacteria.
              Article 0 comments Cited 301 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-journal-id): 0410462
                Journal ID (pubmed-jr-id): 6011
                Journal ID (nlm-ta): Nature
                Journal ID (iso-abbrev): Nature
                Title: Nature
                ISSN (Print): 0028-0836
                ISSN (Electronic): 1476-4687
                Publication date Nihms-submitted: 15 March 2018
                Publication date (Print): 15 November 2017
                Publication date PMC-release: 15 May 2018
                Volume: 551
                Issue: 7680
                Pages: 313-320
                Affiliations
                [1 ]Department of Molecular Biosciences, Institute of Cellular and Molecular Biology, John Ring LaMontagne Center for Infectious Disease, The University of Texas at Austin, Austin, TX USA
                [2 ]School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA USA
                [3 ]Department of Microbiology, University of Washington School of Medicine, Seattle, WA USA, Guangdong Innovative and Entrepreneurial Research Team of Sociomicrobiology Basic Science and Frontier Technology, South China Agricultural University, Guangzhou, China
                Author notes
                [* ]Corresponding Author: E. Peter Greenberg, Department of Microbiology, The University of Washington, Phone: 206-616-2881, epgreen@ 123456uw.edu
                Article
                Accession ID: PMC5870893 Pmcid ID: PMC5870893 Pmc-uid ID: 5870893 Manuscript ID: nihpa950975
                DOI: 10.1038/nature24624
                PMC ID: 5870893
                PubMed ID: 29144467
                SO-VID: a840ed01-347c-4904-b4b5-2857d689ad3a
                History
                Categories
                Subject: Article

                Keywords: anti-virulence strategies,quorum quenching,biogeography,solo receptors,orphan receptors, Pseudomonas aeruginosa , Vibrio ,bacterial communication,Sociomicrobiology
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                Keywords: anti-virulence strategies, quorum quenching, biogeography, solo receptors, orphan receptors, Pseudomonas aeruginosa , Vibrio , bacterial communication, Sociomicrobiology

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