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      Caveolae: from cell biology to animal physiology.

      Pharmacological reviews
      Animals, Caveolae, physiology, ultrastructure, Caveolins, genetics, Cell Membrane, Cholesterol, metabolism, Disease Models, Animal, Evolution, Molecular, Humans, Mice, Mutation, Neoplasms, Oncogenes, Signal Transduction

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          Abstract

          Among the membrane compartments of a cell, vesicles known as "caveolae" have long defied functional characterization. However, since the identification of a family of proteins termed "caveolins", that form and reside in caveolae, a better understanding has emerged. It is now clear that caveolae do not merely play a singular role in the cell, but are pleiotropic in nature-serving to modulate many cellular functions. The purpose of this review is to explicate what is known about caveolins/caveolae and highlight growing areas of caveolar research.

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