MicroRNA-217-5p ameliorates endothelial cell apoptosis induced by ox-LDL by targeting CLIC4.

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Abstract

Endothelial cell apoptosis plays an essential role in the pathogenesis of atherosclerosis. MicroRNAs and chloride intracellular channels (CLICs) have been verified to participate in the endothelial cell apoptosis process, however, the underlying molecular mechanisms are still unclear. The main aim of this study was to investigate the biological effects of microRNA-217-5p (miR-217-5p) and CLIC4 on endothelial cell apoptosis in atherosclerosis.

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Author and article information

Journal

Journal ID (iso-abbrev): Nutr Metab Cardiovasc Dis

Title: Nutrition, metabolism, and cardiovascular diseases : NMCD

Publisher: Elsevier BV

ISSN (Electronic): 1590-3729

ISSN (Print): 0939-4753

Publication date (Electronic): March 09 2020

Volume: 30

Issue: 3

Affiliations

[1 ] Department of Neurology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, People's Republic of China.

[2 ] Department of Neurology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, People's Republic of China. Electronic address: bigr@sj-hospital.org.

Article

Publisher Item ID: S0939-4753(19)30379-5

DOI: 10.1016/j.numecd.2019.09.027

PubMed ID: 31744714

SO-VID: c15d9553-95c5-42e8-a663-9a41c54e54c1

History

Keywords: Atherosclerosis,Endothelial cell,miR-217-5p,Apoptosis,CLIC4

Data availability:

Keywords: Atherosclerosis, Endothelial cell, miR-217-5p, Apoptosis, CLIC4

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