LCZ696 (sacubitril/valsartan) protects against cyclophosphamide-induced nephrotoxicity in adult male rats: Up-regulation of Apelin-13/ACE2, miR-200, and down-regulation of TGF-β/SMAD 2/3 and miR-192.

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Abstract

Cyclophosphamide (CP) is a widely used chemotherapeutic drug. However, the associated nephrotoxicity restricts its clinical use.

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Journal ID (iso-abbrev): Life Sci

Title: Life sciences

Publisher: Elsevier BV

ISSN (Electronic): 1879-0631

ISSN (Print): 0024-3205

Publication date (Electronic): Oct 01 2022

Volume: 306

Affiliations

[1 ] Pharmacology and Toxicology Department, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt. Electronic address: samah.saeed@miuegypt.edu.eg.

[2 ] Pharmacy Practice and Clinical Pharmacy Department, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt. Electronic address: mona.schaalan@miuegypt.edu.eg.

[3 ] Histology Department, Faculty of Medicine, Sohag University, Sohag, Egypt. Electronic address: Sahermohamed@med.sohag.edu.eg.

[4 ] Medical Physiology Department, Kasr Alainy, Faculty of Medicine, Cairo University, Cairo, Egypt; Department of Physiology, Medicine Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia. Electronic address: fatma.e.elsayed@kasralainy.edu.eg.

[5 ] Biochemistry Department, Faculty of Pharmacy, Egyptian Russian University, Cairo, Egypt. Electronic address: Dr_mahamahmoud@hotmail.com.

[6 ] Biochemistry Department, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, Egypt. Electronic address: Soha.hassanin@pharm.mti.edu.eg.

Article

Publisher Item ID: S0024-3205(22)00550-1

DOI: 10.1016/j.lfs.2022.120850

PubMed ID: 35917938

SO-VID: c4baf7bf-f902-4a18-91d4-2da3d98c37a5

History

Keywords: ACE-2,Apelin-13,Cyclophosphamide,LCZ696,Nephrotoxicity,miR-200/192

Data availability:

Keywords: ACE-2, Apelin-13, Cyclophosphamide, LCZ696, Nephrotoxicity, miR-200/192

LCZ696 (sacubitril/valsartan) protects against cyclophosphamide-induced nephrotoxicity in adult male rats: Up-regulation of Apelin-13/ACE2, miR-200, and down-regulation of TGF-β/SMAD 2/3 and miR-192.

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