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Effect of neostigmine on gastroduodenal motility in patients with suspected gastrointestinal motility disorders.
G Parthasarathy
1 ,
K Ravi
1 ,
M Camilleri
1 ,
C Andrews
2 ,
L A Szarka
1 ,
P A Low
3 ,
A R Zinsmeister
4 ,
A E Bharucha
1
Dec 2015
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Abstract
Acetylcholinesterase inhibitors (ACIs), e.g., neostigmine, are known to increase upper and lower gastrointestinal (GI) motility and are used to treat acute colonic pseudoobstruction. However, their effects on gastroduodenal motility in humans are poorly understood. Our hypotheses were that, in patients with suspected GI motility disorders, neostigmine increases gastric and small intestinal motor activity, and these effects are greater in patients with cardiovagal neuropathy, reflecting denervation sensitivity.