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Functional rafts in cell membranes.

Nature

10.1038/42408

9177342

physiology, Sphingolipids, Solubility, Signal Transduction, Membrane Proteins, Membrane Lipids, Humans, Golgi Apparatus, Detergents, Cholesterol, ultrastructure, Cell Membrane, Biological Transport, Animals

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      Abstract

      A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer. It is proposed that these rafts function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.

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