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      A review of factors that influence individual compliance with mass drug administration for elimination of lymphatic filariasis.

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          Abstract

          The success of programs to eliminate lymphatic filariasis (LF) depends in large part on their ability to achieve and sustain high levels of compliance with mass drug administration (MDA). This paper reports results from a comprehensive review of factors that affect compliance with MDA.

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          Control of neglected tropical diseases.

          Peter Hotez, David H. Molyneux, Alan Fenwick … (2007)
          Article 0 comments Cited 526 times – based on 0 reviews     Review now
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            Strategies and tools for the control/elimination of lymphatic filariasis.

            Camilla Ottesen, Amir Karam, Charles B. Duke … (1996)
            Lymphatic filariasis infects 120 million people in 73 countries worldwide and continues to be a worsening problem, especially in Africa and the Indian subcontinent. Elephantiasis, lymphoedema, and genital pathology afflict 44 million men, women and children; another 76 million have parasites in their blood and hidden internal damage to their lymphatic and renal systems. In the past, tools and strategies for the control of the condition were inadequate, but over the last 10 years dramatic research advances have led to new understanding about the severity and impact of the disease, new diagnostic and monitoring tools, and, most importantly, new treatment tools and control strategies. The new strategy aims both at transmission control through community-wide (mass) treatment programmes and at disease control through individual patient management. Annual single-dose co-administration of two drugs (ivermectin + diethylcarbamazine (DEC) or albendazole) reduces blood microfilariae by 99% for a full year; even a single dose of one drug (ivermectin or DEC) administered annually can result in 90% reductions; field studies confirm that such reduction of microfilarial loads and prevalence can interrupt transmission. New approaches to disease control, based on preventing bacterial superinfection, can now halt or even reverse the lymphoedema and elephantiasis sequelae of filarial infection. Recognizing these remarkable technical advances, the successes of recent control programmes, and the biological factors favouring elimination of this infection, the Fiftieth World Health Assembly recently called on WHO and its Member States to establish as a priority the global elimination of lymphatic filariasis as a public health problem.
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              The global programme to eliminate lymphatic filariasis.

              E Ottesen (2000)
              Ten years ago, no one foresaw that in the year 2000 there would be a Global Programme to Eliminate Lymphatic Filariasis (GPELF) that is already 2 years old, active in 18 of the 80 endemic countries, and operating under a wholly new paradigm in public health - a paradigm affirming that public/private sector partnerships are essential in sharing both responsibilities and responses to global health problems. What has driven the LF Elimination Programme to this point? Where it is now headed? What will be required to sustain its momentum? What will its impact be? These are the issues addressed below.
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                Author and article information

                Journal
                Journal ID (iso-abbrev): PLoS Negl Trop Dis
                Title: PLoS neglected tropical diseases
                Publisher: Public Library of Science (PLoS)
                ISSN (Electronic): 1935-2735
                ISSN (Print): 1935-2727
                Publication date (Electronic): Nov 2013
                Volume: 7
                Issue: 11
                Affiliations
                [1 ] Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America ; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
                Article
                Publisher Item ID: PNTD-D-13-00320
                DOI: 10.1371/journal.pntd.0002447
                PMC ID: 3836848
                PubMed ID: 24278486
                SO-VID: b6333ee1-aef5-4b0e-9c9d-f2a042b7e60d
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