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      Epithelial-mesenchymal transitions in development and disease.

      Cell
      Animals, Cell Transformation, Neoplastic, Epithelial Cells, cytology, Gastrulation, Humans, Neoplasm Metastasis, Neoplasms, pathology, Neoplastic Stem Cells

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          Abstract

          The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the body plan and in the differentiation of multiple tissues and organs. EMT also contributes to tissue repair, but it can adversely cause organ fibrosis and promote carcinoma progression through a variety of mechanisms. EMT endows cells with migratory and invasive properties, induces stem cell properties, prevents apoptosis and senescence, and contributes to immunosuppression. Thus, the mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.

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          Author and article information

          Journal
          19945376
          10.1016/j.cell.2009.11.007

          Chemistry
          Animals,Cell Transformation, Neoplastic,Epithelial Cells,cytology,Gastrulation,Humans,Neoplasm Metastasis,Neoplasms,pathology,Neoplastic Stem Cells

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