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      Nanoplasmonic detection of adenosine triphosphate by aptamer regulated self-catalytic growth of single gold nanoparticles.

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          Abstract

          We present a nanoplasmonic aptasensor for adenosine triphosphate (ATP) by using single gold nanoparticles (GNPs) as probes. The specific aptamer-ATP binding induced conformational change could modulate the surface-dependent self-catalytic growth of GNPs, which enabled the detection of ATP with ultra-sensitivity and selectivity.

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          Biosensing with plasmonic nanosensors.

          Jeffrey N Anker, W. Hall, Olga Lyandres … (2008)
          Recent developments have greatly improved the sensitivity of optical sensors based on metal nanoparticle arrays and single nanoparticles. We introduce the localized surface plasmon resonance (LSPR) sensor and describe how its exquisite sensitivity to size, shape and environment can be harnessed to detect molecular binding events and changes in molecular conformation. We then describe recent progress in three areas representing the most significant challenges: pushing sensitivity towards the single-molecule detection limit, combining LSPR with complementary molecular identification techniques such as surface-enhanced Raman spectroscopy, and practical development of sensors and instrumentation for routine use and high-throughput detection. This review highlights several exceptionally promising research directions and discusses how diverse applications of plasmonic nanoparticles can be integrated in the near future.
          Article 0 comments Cited 1277 times – based on 0 reviews     Review now
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            Localized surface plasmon resonance sensors.

            Kathryn Mayer, Jason Hafner (2011)
            Article 0 comments Cited 685 times – based on 0 reviews     Review now
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              Gold nanoparticles for biology and medicine.

              David A Giljohann, Dwight S Seferos, Weston L Daniel … (2010)
              Gold colloids have fascinated scientists for over a century and are now heavily utilized in chemistry, biology, engineering, and medicine. Today these materials can be synthesized reproducibly, modified with seemingly limitless chemical functional groups, and, in certain cases, characterized with atomic-level precision. This Review highlights recent advances in the synthesis, bioconjugation, and cellular uses of gold nanoconjugates. There are now many examples of highly sensitive and selective assays based upon gold nanoconjugates. In recent years, focus has turned to therapeutic possibilities for such materials. Structures which behave as gene-regulating agents, drug carriers, imaging agents, and photoresponsive therapeutics have been developed and studied in the context of cells and many debilitating diseases. These structures are not simply chosen as alternatives to molecule-based systems, but rather for their new physical and chemical properties, which confer substantive advantages in cellular and medical applications.
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                Author and article information

                Journal
                Journal ID (iso-abbrev): Chem. Commun. (Camb.)
                Title: Chemical communications (Cambridge, England)
                Publisher: Royal Society of Chemistry (RSC)
                ISSN (Electronic): 1364-548X
                ISSN (Print): 1359-7345
                Publication date (Electronic): Oct 07 2012
                Volume: 48
                Issue: 77
                Affiliations
                [1 ] State Key Laboratory of Bioreactor Engineering & Department of Chemistry, East China University of Science and Technology, Shanghai, 200237, China.
                Article
                DOI: 10.1039/c2cc34632j
                PubMed ID: 22871726
                SO-VID: 4ab3e6fa-6282-4719-a2ad-bdce38f2f99b
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