1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Early Development of Functional Network Segregation Revealed by Connectomic Analysis of the Preterm Human Brain.

      Read this article at

      ScienceOpenPublisherPubMed
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Human brain functional networks are topologically organized with nontrivial connectivity characteristics such as small-worldness and densely linked hubs to support highly segregated and integrated information processing. However, how they emerge and change at very early developmental phases remains poorly understood. Here, we used resting-state functional MRI and voxel-based graph theory analysis to systematically investigate the topological organization of whole-brain networks in 40 infants aged around 31 to 42 postmenstrual weeks. The functional connectivity strength and heterogeneity increased significantly in primary motor, somatosensory, visual, and auditory regions, but much less in high-order default-mode and executive-control regions. The hub and rich-club structures in primary regions were already present at around 31 postmenstrual weeks and exhibited remarkable expansions with age, accompanied by increased local clustering and shortest path length, indicating a transition from a relatively random to a more organized configuration. Moreover, multivariate pattern analysis using support vector regression revealed that individual brain maturity of preterm babies could be predicted by the network connectivity patterns. Collectively, we highlighted a gradually enhanced functional network segregation manner in the third trimester, which is primarily driven by the rapid increases of functional connectivity of the primary regions, providing crucial insights into the topological development patterns prior to birth.

          Related collections

          Author and article information

          Journal
          Cereb. Cortex
          Cerebral cortex (New York, N.Y. : 1991)
          Oxford University Press (OUP)
          1460-2199
          1047-3211
          Mar 01 2017
          : 27
          : 3
          Affiliations
          [1 ] State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
          [2 ] Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
          [3 ] Department of Pediatrics and.
          [4 ] Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
          [5 ] Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
          Article
          bhw038
          10.1093/cercor/bhw038
          26941380

          preterm, rich club, connectome, functional connectivity, hub

          Comments

          Comment on this article