Saika Ogawa: Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Writing – original draft
Hideki Kitaura:
ORCID: http://orcid.org/0000-0003-3249-4247
Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: Writing – original draftRole: Writing – review & editing
Akiko Kishikawa: Role: Investigation
Jiawei Qi: Role: Investigation
Wei-Ren Shen: Role: Investigation
Fumitoshi Ohori: Role: Investigation
Takahiro Noguchi: Role: Investigation
Aseel Marahleh: Role: Investigation
Yasuhiko Nara: Role: Investigation
Yumiko Ochi: Role: Investigation
Itaru Mizoguchi: Role: Funding acquisitionRole: Investigation
Sakamuri V. Reddy: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
16
October
2019
Publication date Collection: 2019
Volume: 14
Issue: 10
Electronic Location Identifier: e0223989
Affiliations
[001]Division of Orthodontics and Dentofacial Orthopedics, Department of Translational
Medicine, Tohoku University Graduate School of Dentistry, Sendai, Japan
Charles P. Darby Children's Research Institute, UNITED STATES
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-19-20169
DOI: 10.1371/journal.pone.0223989
PMC ID: 6795494
PubMed ID: 31618254
SO-VID: b9e01846-7895-4475-891d-94ad0ba17f36
Copyright © © 2019 Ogawa et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/501100001691, Japan Society for the Promotion of Science;
Award ID: 16K11776
Award Recipient
:
ORCID: http://orcid.org/0000-0003-3249-4247
Hideki Kitaura
Funded by: funder-id http://dx.doi.org/10.13039/501100001691, Japan Society for the Promotion of Science;
Award ID: 19K10397
Award Recipient
:
ORCID: http://orcid.org/0000-0003-3249-4247
Hideki Kitaura
Funded by: funder-id http://dx.doi.org/10.13039/501100001691, Japan Society for the Promotion of Science;
Award ID: 18K09862
Award Recipient
:
Itaru Mizoguchi
This work was supported in part by a JSPS KAKENHI grant from the Japan Society for
the Promotion of Science (No. 16K11776 to H.K.; No. 19K10397 to H.K.; No. 18K09862
to I.M.). The funders had no role in the study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Digestive System
Subject:
Teeth
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Digestive System
Subject:
Teeth
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Head
Subject:
Jaw
Subject:
Teeth
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Head
Subject:
Jaw
Subject:
Teeth
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Bone
Subject:
Osteoclasts
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Bone
Subject:
Osteoclasts
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Bone
Subject:
Osteoclasts
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Bone
Subject:
Osteoclasts
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Connective Tissue Cells
Subject:
Osteoclasts
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Osteoclasts
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Osteoclasts
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Medicine and Health Sciences
Subject:
Oral Medicine
Subject:
Orthodontics
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Connective Tissue Cells
Subject:
Odontoclasts
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Odontoclasts
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Odontoclasts
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Musculoskeletal System
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Musculoskeletal System
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Digestive System
Subject:
Teeth
Subject:
Molars
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Digestive System
Subject:
Teeth
Subject:
Molars
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Head
Subject:
Jaw
Subject:
Teeth
Subject:
Molars
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Head
Subject:
Jaw
Subject:
Teeth
Subject:
Molars
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Connective Tissue Cells
Subject:
Stromal Cells
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Stromal Cells
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Stromal Cells