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      Antioxidant beverages: green tea intake and coronary artery disease.

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          Abstract

          Coronary artery disease (CAD) is recognized as an inflammatory disease. In the present study, we investigated the effect of green tea consumption on plasma inflammatory markers and the association between green tea consumption and CAD. In 22 healthy volunteers, green tea consumption (7 cups/day) significantly decreased serum malondialdehyde-modified low-density lipoprotein (MDA-LDL) concentrations, whereas green tea consumption tended to decrease plasma C-reactive protein and interleukin (IL)-6 concentrations. In 725 patients undergoing coronary angiography, the percentage of patients drinking <1 cup/day of green tea was higher in patients with myocardial infarction (MI) than in CAD patients without MI and patients without CAD (29% vs. 15% and 18%, P < 0.01). Green tea consumption was found to be inversely associated with MI in Japanese patients. The protective effect of green tea against atherosclerosis is more likely to be because of the inhibitory effect of LDL oxidation than because of anti-inflammatory effect.

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          Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.

          D. Steinberg, S. Parthasarathy, T E Carew … (1989)
          Article 0 comments Cited 384 times – based on 0 reviews     Review now
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            Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study.

            Michael G. L. Hertog (1995)
            To determine whether flavonoid intake explains differences in mortality rates from chronic diseases between populations. Cross-cultural correlation study. Sixteen cohorts of the Seven Countries Study in whom flavonoid intake at baseline around 1960 was estimated by flavonoid analysis of equivalent food composites that represented the average diet in the cohorts. Mortality from coronary heart disease, cancer (various sites), and all causes in the 16 cohorts after 25 years of follow-up. Average intake of antioxidant flavonoids was inversely associated with mortality from coronary heart disease and explained about 25% of the variance in coronary heart disease rates in the 16 cohorts. In multivariate analysis, intake of saturated fat (73%; P = 0.0001), flavonoid intake (8%, P = .01), and percentage of smokers per cohort (9%; P = .03) explained together, independent of intake of alcohol and antioxidant vitamins, 90% of the variance in coronary heart disease rates. Flavonoid intake was not independently associated with mortality from other causes. Average flavonoid intake may partly contribute to differences in coronary heart disease mortality across populations, but it does not seem to be an important determinant of cancer mortality.
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              C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992.

              W. Koenig, M Sund, M. Fröhlich … (1999)
              Inflammatory reactions in coronary plaques play an important role in the pathogenesis of acute atherothrombotic events; inflammation elsewhere is also associated with both atherogenesis generally and its thrombotic complications. Recent studies indicate that systemic markers of inflammation can identify subjects at high risk of coronary events. We used a sensitive immunoradiometric assay to examine the association of serum C-reactive protein (CRP) with the incidence of first major coronary heart disease (CHD) event in 936 men 45 to 64 years of age. The subjects, who were sampled at random from the general population, participated in the first MONICA Augsburg survey (1984 to 1985) and were followed for 8 years. There was a positive and statistically significant unadjusted relationship, which was linear on the log-hazards scale, between CRP values and the incidence of CHD events (n=53). The hazard rate ratio (HRR) of CHD events associated with a 1-SD increase in log-CRP level was 1.67 (95% CI, 1.29 to 2. 17). After adjustment for age, the HRR was 1.60 (95% CI, 1.23 to 2. 08). Adjusting further for smoking behavior, the only variable selected from a variety of potential confounders by a forward stepping process with a 5% change in the relative risk of CRP as the selection criterion, yielded an HRR of 1.50 (95% CI, 1.14 to 1.97). These results confirm the prognostic relevance of CRP, a sensitive systemic marker of inflammation, to the risk of CHD in a large, randomly selected cohort of initially healthy middle-aged men. They suggest that low-grade inflammation is involved in pathogenesis of atherosclerosis, especially its thrombo-occlusive complications.
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                Author and article information

                Journal
                Journal ID (iso-abbrev): Clin Med Insights Cardiol
                Title: Clinical Medicine Insights. Cardiology
                Publisher: SAGE Publications
                ISSN: 1179-5468
                ISSN (Print): 1179-5468
                Publication date (Electronic): 2014
                Volume: 8
                Issue: Suppl 3
                Affiliations
                [1 ] Utsunomiya University, Tochigi, Japan.
                [2 ] Ochanomizu University, Tokyo, Japan.
                [3 ] National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
                Article
                Publisher Item ID: cmc-suppl.3-2014-007
                DOI: 10.4137/CMC.S17072
                PMC ID: 4274049
                PubMed ID: 25574146
                SO-VID: d6a4017e-b631-4f59-93bf-2b69ff037ece
                History

                Keywords: antioxidant,coronary artery disease,green tea,inflammation,myocardial infarction
                Data availability:
                Keywords: antioxidant, coronary artery disease, green tea, inflammation, myocardial infarction

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