There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

For more than a quarter of a century, macrophage migration inhibitory factor (MIF) has been a mysterious cytokine. In recent years, MIF has assumed an important role as a pivotal regulator of innate immunity. MIF is an integral component of the host antimicrobial alarm system and stress response that promotes the pro-inflammatory functions of immune cells. A rapidly increasing amount of literature indicates that MIF is implicated in the pathogenesis of sepsis, and inflammatory and autoimmune diseases, suggesting that MIF-directed therapies might offer new treatment opportunities for human diseases in the future.

Related collections

Most cited references 118

Record: found
Abstract: not found
Article: not found

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

Yigong Shi, Joan Massagué (2003)

0 comments Cited 450 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Phylogenetic perspectives in innate immunity.

J A Hoffmann, F C Kafatos, C A Janeway … (1999)

The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.

0 comments Cited 338 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Innate immune sensing and its roots: the story of endotoxin.

Bruce Beutler, Ernst Rietschel (2003)

How does the host sense pathogens? Our present concepts grew directly from longstanding efforts to understand infectious disease: how microbes harm the host, what molecules are sensed and, ultimately, the nature of the receptors that the host uses. The discovery of the host sensors--the Toll-like receptors--was rooted in chemical, biological and genetic analyses that centred on a bacterial poison, termed endotoxin.

0 comments Cited 318 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

PubMed ID:: 14502271

DOI:: 10.1038/nri1200

ScienceOpen disciplines: Chemistry

Keywords: Animals,Autoimmune Diseases,etiology,immunology,Humans,Immunity, Innate,genetics,Inflammation,Macrophage Migration-Inhibitory Factors,Macrophages,Sepsis

Data availability:

ScienceOpen disciplines: Chemistry

Keywords: Animals, Autoimmune Diseases, etiology, immunology, Humans, Immunity, Innate, genetics, Inflammation, Macrophage Migration-Inhibitory Factors, Macrophages, Sepsis

Macrophage migration inhibitory factor: a regulator of innate immunity.

Read this article at

Abstract

Related collections

Plant MYBs

Most cited references 118

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

Phylogenetic perspectives in innate immunity.

Innate immune sensing and its roots: the story of endotoxin.

Author and article information

Journal

Comments

Comment on this article

Similar content 204

Cited by 466

Most referenced authors 2,169