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      The different roles of ER subtypes in cancer biology and therapy.

      Nature reviews. Cancer
      Animals, Estrogen Receptor alpha, physiology, Estrogen Receptor beta, Humans, Neoplasms, drug therapy, physiopathology, Prognosis, Protein Isoforms

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          Abstract

          By eliciting distinct transcriptional responses, the oestrogen receptors (ERs) ERα and ERβ exert opposite effects on cellular processes that include proliferation, apoptosis and migration and that differentially influence the development and the progression of cancer. Perturbation of ER subtype-specific expression has been detected in various types of cancer, and the differences in the expression of ERs are correlated with the clinical outcome. The changes in the bioavailability of ERs in tumours, together with their specific biological functions, promote the selective restoration of their activity as one of the major therapeutic approaches for hormone-dependent cancers.

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          Author and article information

          Journal
          21779010
          10.1038/nrc3093

          Chemistry
          Animals,Estrogen Receptor alpha,physiology,Estrogen Receptor beta,Humans,Neoplasms,drug therapy,physiopathology,Prognosis,Protein Isoforms

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